Apr 23, 2020

Interplay of host regulatory network on SARS-CoV-2 binding and replication machinery

BioRxiv : the Preprint Server for Biology
Ahmed ShiekR. V

Abstract

We dissect the mechanism of SARS-CoV-2 in human lung hosts from the initial phase of receptor binding to viral replication machinery using a systems biological approach. Two independent lung protein interactome were contracted to revel the signaling process on receptor activation and host protein hijacking machinery in the pathogenesis virus. Most of the functional hubs interactome proteins were associated with SARS-CoV-2 infection. Also, 52% of the proteins related to cardiovascular disease, and they involved in viral infection, which causes vulnerability and severity in the risk individuals. We also showed five interconnecting cascades between hubs of both networks that explore the preparation of the optimal environment in the host for viral replication initiated at the phase of receptor attachment. Interestingly, we propose that seven potential miRNAs targeting the intermediate phase that connects receptor and viral replication process a better choice as a drug for SARS-CoV-2.

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Mentioned in this Paper

Genome
Genes
Technology, Health Care
Environment
Medical Devices
Gene Expression
Microbial
Pharmaceutical Preparations
Species
Analysis

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