Integrated breast conservation and intraoperative radiation therapy

The Breast : Official Journal of the European Society of Mastology
R OrecchiaM C Leonardi

Abstract

The introduction of innovative radiotherapy approaches for early breast cancer patients is rapidly changing the radiation oncologists' attitude and their expectations to obtain a good local control while decreasing morbidity therefore improving patient's quality of life. Intraoperative radiotherapy is a very attractive treatment modality in the multidisciplinary approach to breast conservation as is testified by the rapidly growing number of patients accrued in numerous studies all over Europe since 2000. A major advantage of intraoperative radiotherapy in breast cancer treatment is the administration of a large dose of radiation directly to the tumour bed, avoiding the possible geographic miss. Accurate localization and precise definition of the tumour bed volume is essential to achieve maximal efficacy in terms of local control while minimizing unnecessary damage to the normal breast tissue. Intraoperative radiotherapy reduces radiation exposure of the skin, lung, heart and normal subcutaneous tissues thus contributing to the low incidence of side effects and the generally excellent cosmetic results. Compared to other intraoperative techniques, the superiority of intraoperative radiotherapy appears to be the high homogeneity ...Continue Reading

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Citations

Mar 7, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·F A CalvoC Ferrer
Nov 2, 2011·The Breast : Official Journal of the European Society of Mastology·Roberto Orecchia, Maria Cristina Leonardo
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Jan 1, 2011·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Agata Kacprowska, Jacek Jassem

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