Integrated communications between cyclooxygenase-2 and Alzheimer's disease

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Pei-Pei Guan, Pu Wang

Abstract

Elevated levels of cyclooxygenase-2 (COX-2) and prostaglandins (PGs) are involved in the pathogenesis of Alzheimer's disease (AD), which is characterized by the accumulation of β-amyloid protein (Aβ) and tau hyperphosphorylation. However, the gaps in our knowledge of the roles of COX-2 and PGs in AD have not been filled. Here, we summarized the literature showing that COX-2 dysregulation obviously influences abnormal cleavage of β-amyloid precursor protein, aggregation and deposition of Aβ in β-amyloid plaques and the inclusion of phosphorylated tau in neurofibrillary tangles. Neuroinflammation, oxidative stress, synaptic plasticity, neurotoxicity, autophagy, and apoptosis have been assessed to elucidate the mechanisms of COX-2 regulation of AD. Notably, an imbalance of these factors ultimately produces cognitive decline. The current review substantiates our understanding of the mechanisms of COX-2-induced AD and establishes foundations for the design of feasible therapeutic strategies to treat AD.-Guan, P.-P., Wang, P. Integrated communications between cyclooxygenase-2 and Alzheimer's disease.

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Citations

Oct 17, 2019·Journal of Clinical Medicine·Raluca Ioana TeleanuDaniel Mihai Teleanu
Aug 10, 2019·Oxidative Medicine and Cellular Longevity·Natalia A StefanovaNataliya G Kolosova
Apr 12, 2020·International Journal of Molecular Sciences·Karolina WakulikKazimierz Gąsiorowski
Jul 8, 2020·Pharmacological Reports : PR·J S Dileep KumarAkiva Mintz
Jan 28, 2020·Journal of Alzheimer's Disease : JAD·Fúlvio R MendesSylvain Doré
May 24, 2020·Journal of Alzheimer's Disease : JAD·Shuoqi Chen, Jianping Jia
Nov 25, 2020·Human Molecular Genetics·Serena J AleoClaudia Zanna
Mar 10, 2021·ACS Chemical Neuroscience·Ahmad SaitPhilip J R Day
Feb 20, 2021·European Journal of Pharmacology·Aihong YangRui Shen
Jul 9, 2020·Pharmacology & Therapeutics·Jane A MitchellTimothy D Warner
Aug 14, 2021·Metabolic Brain Disease·Awanish MishraNavneet Khurana

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