Integrated delivery of antiretroviral treatment and pre-exposure prophylaxis to HIV-1 serodiscordant couples in East Africa: a qualitative evaluation study in Uganda

Journal of the International AIDS Society
Norma WareElly Katabira

Abstract

Serodiscordant couples are a priority population for delivery of new HIV prevention interventions in Africa. An integrated strategy of delivering time-limited, oral pre-exposure prophylaxis (PrEP) to uninfected partners in serodiscordant couples as a bridge to long-term antiretroviral treatment (ART) for infected partners has been implemented in East Africa, nearly eliminating new infections. We conducted a qualitative evaluation of the integrated strategy in Uganda, to better understand its success. Data collection consisted of 274 in-depth interviews with 93 participating couples, and 55 observations of clinical encounters between couples and healthcare providers. An inductive content analytic approach aimed at understanding and interpreting couples' experiences of the integrated strategy was used to examine the data. Analysis sought to characterize: (1) key aspects of services provided; (2) what the services meant to recipients; and (3) how couples managed the integrated strategy. Themes were identified in each domain, and represented as descriptive categories. Categories were grouped inductively into more general propositions based on shared content. Propositions were linked and interpreted to explain "why the integrated st...Continue Reading

References

Sep 9, 2005·Social Science & Medicine·Megan A LewisKaren M Emmons
Oct 6, 2005·Qualitative Health Research·Hsiu-Fang Hsieh, Sarah E Shannon
Nov 26, 2010·The New England Journal of Medicine·Robert M GrantUNKNOWN iPrEx Study Team
Jul 20, 2011·The New England Journal of Medicine·Myron S CohenUNKNOWN HPTN 052 Study Team
Jan 24, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Norma C WareDavid R Bangsberg
Jul 13, 2012·The New England Journal of Medicine·Jared M BaetenUNKNOWN Partners PrEP Study Team
Jul 13, 2012·The New England Journal of Medicine·Michael C ThigpenUNKNOWN TDF2 Study Group
Nov 29, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Erin M KahleUNKNOWN Partners in Prevention HSVHIV Transmission Study and the Partners PrEP Study Teams
Nov 14, 2014·Journal of the International AIDS Society·Nikola FowlerLesley Roberts
Nov 5, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Amy CorneliLut Van Damme
Dec 2, 2015·The New England Journal of Medicine·Jean-Michel MolinaUNKNOWN ANRS IPERGAY Study Group
Jul 13, 2016·JAMA : the Journal of the American Medical Association·Alison J RodgerUNKNOWN PARTNER Study Group
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Dec 6, 2017·Journal of the International AIDS Society·Fred C SemitalaElvin H Geng

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Citations

Jan 19, 2019·Journal of the International AIDS Society·Edith Nakku-JolobaNorma C Ware
Nov 26, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Norma C Ware
Jul 14, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Randy StalterUNKNOWN Partners Demonstration Project Team
May 31, 2019·The Journal of Pharmacy and Pharmacology·Pui Khee YapDinesh Kumar Chellappan
Oct 15, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hannah N GilbertNorma C Ware
Jan 26, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Fernandos K OngollyGabrielle O'Malley

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NCT02775929

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