Integrated diagnostics of diffuse astrocytic and oligodendroglial tumors. German version

Der Pathologe
B Malzkorn, G Reifenberger

Abstract

Diffuse astrocytic and oligodendroglial gliomas are the most common neuroepithelial tumors. Their classification is based on the integration of histological and molecular findings according to the classification of tumors of the central nervous system published by the World Health Organization (WHO) in 2016. This review describes the different entities and variants of diffuse gliomas and summarizes the current diagnostic criteria for these tumors. Based on the 2016 WHO classification and selected other publications, the histomolecular diagnostics of diffuse gliomas is presented and illustrated. Diffuse gliomas are divided into isocitrate dehydrogenase (IDH)-mutant or IDH-wildtype gliomas by detection of mutations in the IDH1 or IDH2 genes. Among the IDH-mutant gliomas, oligodendroglial tumors are characterized by combined losses of chromosome arms 1p and 19q. Loss of nuclear expression of the ATRX protein is a marker of IDH- mutant astrocytic gliomas. Glioblastoma, IDH-wildtype, is the most common diffuse glioma. Diffuse and anaplastic astrocytic gliomas without IDH mutation should be further evaluated for molecular features of glioblastoma, IDH-wildtype. Diffuse gliomas in the thalamus, brainstem, or spinal cord carrying a his...Continue Reading

References

Jun 20, 2012·Journal of Neuropathology and Experimental Neurology·Cristiane M IdaCaterina Giannini
Oct 24, 2015·Acta Neuropathologica·Ulrich HerrlingerGuido Reifenberger
Dec 30, 2016·Nature Reviews. Clinical Oncology·Guido ReifenbergerMichael Weller
Apr 19, 2017·Journal of Neuropathology and Experimental Neurology·Valeria BarresiSabrina Rossi
May 10, 2017·The Lancet Oncology·Michael WellerUNKNOWN European Association for Neuro-Oncology (EANO) Task Force on Gliomas
Jan 27, 2018·Acta Neuropathologica·David N LouisMartin van den Bent
Mar 15, 2018·Nature·David CapperStefan M Pfister
Mar 17, 2018·Seminars in Neurology·Andreas von DeimlingDavid N Louis
Apr 11, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·Karisa C SchreckStuart A Grossman
Apr 25, 2018·Acta Neuropathologica·Mitsuaki ShirahataAndreas von Deimling
Nov 25, 2018·Acta Neuropathologica Communications·Nathalie E SynhaeveHendrikus J Dubbink

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Tomohiro OkudaKoji Iihara
The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica
B Pollo
© 2022 Meta ULC. All rights reserved