PMID: 9185693Jun 11, 1997Paper

Integrated Epstein-Barr virus (EBV) and chromosomal abnormality in chronic active EBV infection

International Journal of Cancer. Journal International Du Cancer
K OhshimaM Kikuchi

Abstract

In order to examine the role of Epstein-Barr virus (EBV) in the pathogenesis of chronic active EBV infection (CAEBV), we investigated whether or not EBV integration into the human genome is associated with any chromosonal abnormality. We therefore analyzed 4 cases of CAEBV: 2 cases showed a normal karyotype, while one had an oligo-clonal 6th chromosomal abnormality and the fourth had a clonal 6th deletion (q15q23). In addition, the case with an oligo-clonal abnormality also had oligo-clonal EBV terminal repeat (TR) bands, while the case with a clonal abnormality showed a clonal TR band. In contrast, the 2 cases with a normal karyotype showed no clonal band. Two-color fluorescence in situ hybridization (FISH) was used to detect the integrated EBV and the 6th chromosomal site. The presence of integrated EBV into the 6th chromosome was not frequent in the 2 cases with a normal karyotype, but it was statistically frequent in the case with an oligo-clonal 6th abnormality. In the case with a clonal 6th deletion, integration in the 6th chromosome was also slightly higher than that in the other chromosomes. In CAEBV, integrated EBV might thus be associated both with chromosomal abnormality and with pathogenesis.

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Citations

Aug 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sibille HummeAloys Schepers
May 10, 2002·Leukemia & Lymphoma·Koichi OhshimaMasahiro Kikuchi
Feb 23, 2017·Journal of Medical Virology·Hongzai GuanBing Luo
Dec 23, 2008·Advances in Anatomic Pathology·Siok-Bian Ng, Joseph D Khoury
Sep 3, 2005·American Journal of Hematology·Motohiko OkanoShinsaku Imashuku
Nov 17, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Elena E LeenmanValia S Lestou
Jan 6, 2006·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·Rianne LudererSteven F T Thijsen
Jun 3, 2021·Cancers·Yuichiro HatanoAkira Hara

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