Integrated gene networks in breast cancer development.

Functional & Integrative Genomics
Ivana RatkajSandra Kraljevic Pavelic

Abstract

Breast cancer is a complex and heterogenous disease. Classical molecular medical approaches cannot fully understand and comprehend its pathogenesis. In this review, the development of new biological markers for the early detection and creation of guided and specific therapy of breast cancer are discussed in light of the rapid advances in the "omics". Results of cancer research in combination with large-scale methods that examine the expression status of genes and proteins have identified a large number of new biomarkers as well as confirmed the human growth hormone as an important player in the pathogenesis of this disease through its autocrine regulation where it influences the activation of Pax5 and HOXA1 gene networks.

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Feb 26, 2010·Functional & Integrative Genomics·R AppelsM Bellgard
May 13, 2014·BioMed Research International·Binbing LingJian Yang
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Jan 1, 2011·Expert Review of Endocrinology & Metabolism·Yash ChhabraAndrew J Brooks

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