Integrated Immunohistochemical Study on Small-Cell Carcinoma of the Lung Focusing on Transcription and Co-Transcription Factors

Diagnostics
Younosuke SatoTakaaki Ito

Abstract

Small-cell lung cancer (SCLC) is an aggressive malignant cancer that is classified into four subtypes based on the expression of the following key transcription and co-transcription factors: ASCL1, NEUROD1, YAP1, and POU2F3. The protein expression levels of these key molecules may be important for the formation of SCLC characteristics in a molecular subtype-specific manner. We expect that immunohistochemistry (IHC) of these molecules may facilitate the diagnosis of the specific SCLC molecular subtype and aid in the appropriate selection of individualized treatments. We attempted IHC of the four key factors and 26 candidate SCLC target molecules selected from the gene expression omnibus datasets of 47 SCLC samples, which were grouped based on positive or negative results for the four key molecules. We examined differences in the expression levels of the candidate targets and key molecules. ASCL1 showed the highest positive rate in SCLC samples, and significant differences were observed in the expression levels of some target molecules between the ASCL1-positive and ASCL1-negative groups. Furthermore, the four key molecules were coordinately and simultaneously expressed in SCLC cells. An IHC study of ASCL1-positive samples showed...Continue Reading

References

Sep 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ramaswamy GovindanJay Piccirillo
Feb 11, 2010·The Oncologist·Thomas E Stinchcombe, Elizabeth M Gore
Jul 16, 2010·Current Oncology Reports·Estelamari Rodriguez, Rogerio C Lilenbaum
Aug 10, 2010·Virchows Archiv : an International Journal of Pathology·Stefano La RosaCarlo Capella
Apr 19, 2011·Seminars in Respiratory and Critical Care Medicine·Gregory P Kalemkerian
Jul 28, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anne M SchultheisHans-Ulrich Schildhaus
Jun 4, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hassan WaelTakaaki Ito
Jul 12, 2014·Journal of Cancer Research and Clinical Oncology·Rita de Cássia S AlvesAdriana Vial Roehe
Aug 1, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
Jul 15, 2015·Nature·Julie GeorgeRoman K Thomas
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisUNKNOWN WHO Panel
Sep 5, 2015·International Journal of Cancer. Journal International Du Cancer·Lydia MederReinhard Buettner
Oct 21, 2015·The American Journal of Pathology·Kosuke FujinoTakaaki Ito
Jan 26, 2016·International Journal of Molecular Sciences·Yuhang ZhouKa Fai To
Feb 4, 2016·Journal of Cancer Research and Clinical Oncology·Wael Abdo HassanTakaaki Ito
May 4, 2016·Current Drug Targets·Giuseppe Lo RussoMarina Chiara Garassino
Oct 30, 2016·Cancer Science·Takeshi ItoYoshinori Murakami
Nov 5, 2016·Science·Ludmil B AlexandrovMichael R Stratton
Dec 22, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Erik ThunnissenMasayuki Noguchi
Jul 2, 2017·Pathology·Yamato MotookaTakaaki Ito
Oct 28, 2017·Nature Reviews. Cancer·Adi F GazdarJohn D Minna
Mar 17, 2018·Expert Review of Anticancer Therapy·Antonio RossiRaffaele Califano
Jun 28, 2018·Genes & Development·Yu-Han HuangChristopher R Vakoc
Oct 4, 2018·The New England Journal of Medicine·Leora HornUNKNOWN IMpower133 Study Group
Mar 31, 2019·Nature Reviews. Cancer·Charles M RudinAdi F Gazdar
May 10, 2019·The Oncologist·Megumi FurutaUNKNOWN Hokkaido Lung Cancer Clinical Study Group
Jun 12, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yuki IkematsuIsamu Okamoto
Aug 18, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yuki TenjinTakaaki Ito

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Methods Mentioned

BETA
electron

Software Mentioned

R
R Foundation for Statistical Computing

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