Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum

Bioorganic & Medicinal Chemistry Letters
Amit K GuptaMridula Saxena

Abstract

A common feature pharmacophore with two hydrogen-bond acceptor and one aromatic hydrophobic feature has been generated using seven active flavonoids. Docking studies of these compounds well corroborates with the pharmacophore model. Therefore models could be useful for identification of potential novel FAS-II inhibitors.

Citations

Apr 26, 2012·Journal of Chemical Information and Modeling·Amit K GuptaAnil K Saxena
Jul 26, 2011·Drug Discovery Today·Frances WatkinsAlberto Sanchez-Medina
Apr 11, 2012·Chemical Biology & Drug Design·Tabish Qidwai, Feroz Khan
Jan 20, 2017·Chemical Biology & Drug Design·Chandra S AzadAnil K Saxena
Apr 7, 2012·Pharmaceutical Biology·Caio Guedes BraguinePatrícia Mendonça Pauletti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.