Integrated logic gate for fluorescence turn-on detection of histidine and cysteine based on Ag/Au bimetallic nanoclusters-Cu²⁺ ensemble

ACS Applied Materials & Interfaces
Jian SunXiurong Yang

Abstract

By means of employing 11-mercaptoundecanoic acid (11-MUA) as a reducing agent and protecting ligand, we present straightforward one-pot preparation of fluorescent Ag/Au bimetallic nanoclusters (namely AgAuNCs@11-MUA) from AgNO3 and HAuCl4 in alkaline aqueous solution at room temperature. It is found that the fluorescence of AgAuNCs@11-MUA has been selectively quenched by Cu(2+) ions, and the nonfluorescence off-state of the as-prepared AgAuNCs@11-MUA-Cu(2+) ensemble can be effectively switched on upon the addition of histidine and cysteine. By incorporating Ni(2+) ions and N-ethylmaleimide, this phenomenon is further exploited as an integrated logic gate and a specific fluorescence turn-on assay for selectively and sensitively sensing histidine and cysteine has been designed and established based on the original noncovalent AgAuNCs@11-MUA-Cu(2+) ensemble. Under the optimal conditions, histidine and cysteine can be detected in the concentration ranges of 0.25-9 and 0.25-7 μM; besides, the detection limits are found to be 87 and 111 nM (S/N = 3), respectively. Furthermore, we demonstrate that the proposed AgAuNCs@11-MUA-based fluorescent assay can be successfully utilized for biological fluids sample analysis.

References

Feb 1, 1982·Analytical Chemistry·P M Kovach, M E Meyerhoff
Jun 1, 1997·Current Eye Research·Y KusakariM Tamai
Mar 24, 1998·Annual Review of Medicine·H RefsumS E Vollset
Feb 15, 2002·The New England Journal of Medicine·Sudha SeshadriPhilip A Wolf
Jun 22, 2005·Chemical Communications : Chem Comm·Yanyan FuDaoben Zhu
Aug 4, 2007·Angewandte Chemie·Chih-Ching HuangHuan-Tsung Chang
Jun 10, 2008·Nano Letters·Ziyang HuoPeidong Yang
Jun 28, 2008·Chemical Reviews·Konrad Szaciłowski
Jul 30, 2011·Chemical Society Reviews·Ying Zhou, Juyoung Yoon
Oct 28, 2011·Analytical Chemistry·Wei-Yu ChenHuan-Tsung Chang
Jun 19, 2012·Nanoscale·Jie ZhengJinbin Liu
Mar 21, 2013·Chemistry, an Asian Journal·Xun YuanJianping Xie
Apr 13, 2013·Chemical Communications : Chem Comm·Mingjie WeiShouzhuo Yao
Sep 17, 2013·Angewandte Chemie·Li ShangG Ulrich Nienhaus
Nov 23, 2013·Chemical Communications : Chem Comm·Zhentao LuoJianping Xie
Dec 18, 2013·Chemical Society Reviews·Jing-Juan XuHong-Yuan Chen
Jan 9, 2014·Accounts of Chemical Research·Fei PengYao He
Feb 27, 2014·ACS Applied Materials & Interfaces·Subhasish RoyArindam Banerjee
Apr 16, 2014·ACS Applied Materials & Interfaces·Rong-Cing HuangChih-Ching Huang
Jun 6, 2014·Chemical Communications : Chem Comm·Zhiqin YuanHuan-Tsung Chang

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Citations

Jun 16, 2017·The Journal of Physical Chemistry Letters·Hamed AkbarzadehAmir Nasser Shamkhali
Nov 8, 2018·Chemical Communications : Chem Comm·Yang LiuWenwan Zhong
Feb 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yaqian HanYuanhong Xu
Feb 6, 2019·Journal of Analytical Methods in Chemistry·Mingxian LiuXiupei Yang
Feb 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shenghao XuXiliang Luo
Aug 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sanjeeb SutradharArchita Patnaik
Dec 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Puneet Khandelwal, Pankaj Poddar
Aug 15, 2019·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Martin SchnedlitzWolfgang E Ernst
Sep 30, 2017·The Journal of Physical Chemistry Letters·Hamed AkbarzadehSamira Ramezanzadeh
Aug 9, 2020·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Martin SchnedlitzWolfgang E Ernst

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