Integrated microreactors for reaction automation: new approaches to reaction development

Annual Review of Analytical Chemistry
Jonathan P McMullen, Klavs F Jensen

Abstract

Applications of microsystems (microreactors) in continuous-flow chemistry have expanded rapidly over the past two decades, with numerous reports of higher conversions and yields compared to conventional batch benchtop equipment. Synthesis applications are enhanced by chemical information gained from integrating microreactor components with sensors, actuators, and automated fluid handling. Moreover, miniaturized systems allow experiments on well-defined samples at conditions not easily accessed by conventional means, such as reactions at high pressure and temperatures. The wealth of synthesis information that could potentially be acquired through use of microreactors integrated with physical sensors and analytical chemistry techniques for online reaction monitoring has not yet been well explored. The increased efficiency resulting from use of continuous-flow microreactor platforms to automate reaction screening and optimization encourages a shift from current batchwise chemical reaction development to this new approach. We review advances in this new area and provide application examples of online monitoring and automation.

References

Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·A T Woolley, R A Mathies
Jan 14, 2000·Electrophoresis·H Becker, C Gärtner
Mar 28, 2002·Journal of Biotechnology·H Becker, C Gärtner
Sep 28, 2002·Science·Todd ThorsenStephen R Quake
Feb 22, 2003·Angewandte Chemie·Helen SongRustem F Ismagilov
Jun 27, 2003·Current Opinion in Chemical Biology·Paul Watts, Stephen J Haswell
Nov 20, 2003·Journal of the American Chemical Society·Helen Song, Rustem F Ismagilov
Jan 24, 2004·Chemical Communications : Chem Comm·Robert C R Wootton, Andrew J DeMello
Apr 22, 2004·Lab on a Chip·Eduardo Garcia-EgidoBrian H Warrington
Apr 22, 2004·Lab on a Chip·Glenn M Walker, David J Beebe
Apr 22, 2004·Lab on a Chip·Miryam Fernandez-SuarezBrian H Warrington
Jul 23, 2004·Lab on a Chip·C FüttererJ-L Viovy
Jul 23, 2004·Lab on a Chip·Regina Knitter, Marcel A Liauw
Sep 24, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Saif A KhanKlavs F Jensen
Nov 2, 2004·Analytical Chemistry·Rachel Herzig-MarxKlavs F Jensen
Nov 13, 2004·Analytical Chemistry·Tiina J KauppilaRisto Kostiainen
Nov 27, 2004·Electrophoresis·Natalia PiehlDetlev Belder
Jan 27, 2005·Chemical Reviews·Jamelyn D HolladayEvan Jones
Jan 27, 2005·Chemical Communications : Chem Comm·Daniel M RatnerPeter H Seeberger
Feb 9, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Axel GüntherKlavs F Jensen
Feb 24, 2005·Chemical Society Reviews·Paul Watts, Stephen J Haswell
Feb 24, 2005·Lab on a Chip·Henk WensinkAlbert van den Berg
Feb 24, 2005·Lab on a Chip·Samuel M StavisHarold G Craighead
Jul 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Nicolae DameanGeorge M Whitesides
Sep 13, 2005·Current Opinion in Structural Biology·Bo ZhengRustem F Ismagilov
Feb 24, 2006·Journal of the American Chemical Society·Takuji HatakeyamaRustem F Ismagilov
Mar 2, 2006·Mass Spectrometry Reviews·Iulia M LazarFrantisek Foret
Mar 30, 2006·Journal of Chromatography. a·Chi-Yuan ShihYu-Chong Tai
Jun 15, 2006·Analytical Chemistry·Petra S DittrichAndreas Manz
Jul 28, 2006·Nature·George M Whitesides
Jul 28, 2006·Nature·Jamil El-AliKlavs F Jensen
Sep 23, 2006·Chemistry : a European Journal·Karolin GeyerPeter H Seeberger
Dec 15, 2006·Analytical Chemistry·Matthew B KerbyAnubhav Tripathi
Jan 26, 2007·Chemical Communications : Chem Comm·Paul Watts, Charlotte Wiles
Feb 3, 2007·Lab on a Chip·Jason G KraljKlavs F Jensen

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Citations

May 25, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Bernard AmaraesekeraR Michael van Dam
Dec 14, 2011·Analytical Chemistry·Piro SiutiMitchel J Doktycz
Oct 25, 2013·Nature Chemistry·Katherine S ElviraAndrew J deMello
Jan 3, 2012·Proceedings of the National Academy of Sciences of the United States of America·Pei Yuin KengR Michael van Dam
Jun 5, 2012·Biomicrofluidics·Wolfgang BucheggerMichael Vellekoop
Apr 10, 2012·Bioscience, Biotechnology, and Biochemistry·Mayumi NakamuraKiichiro Totani
Jul 24, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Albert E Cervera-PadrellKrist V Gernaey
May 7, 2011·Trends in Biotechnology·Juan M BolivarBernd Nidetzky
Apr 14, 2012·Biophysical Chemistry·Alexander Scheeline, Rachel L Behrens
Aug 16, 2016·Accounts of Chemical Research·Brandon J Reizman, Klavs F Jensen
Jun 2, 2017·Chemical Reviews·Matthew B PlutschackPeter H Seeberger
May 2, 2017·Annual Review of Chemical and Biomolecular Engineering·Joshua A SelekmanJacob Janey
Mar 25, 2017·Chemical Communications : Chem Comm·Jorge García-LacunaJavier Pérez-Castells
Jun 5, 2015·Lab on a Chip·T-A MeierD Belder
May 23, 2015·Organic & Biomolecular Chemistry·Leandro de C AlvesTimothy J Brocksom
Jun 6, 2017·Reaction Chemistry & Engineering·Christopher A HoneFrans L Muller
Dec 9, 2016·Reaction Chemistry & Engineering·Brandon J ReizmanKlavs F Jensen
Jul 24, 2015·Chemical Society Reviews·Hannes P L GemoetsTimothy Noël
Aug 1, 2018·Organic & Biomolecular Chemistry·Marcus Baumann
Sep 29, 2011·Angewandte Chemie·Stefanie FritzscheDetlev Belder
Mar 29, 2011·Angewandte Chemie·Andrew J ParrottMartyn Poliakoff
Aug 21, 2012·Chemistry : a European Journal·Aiichiro NagakiJun-ichi Yoshida
Aug 8, 2015·ChemistryOpen·István M MándityFerenc Fülöp
May 28, 2014·Chemistry : a European Journal·Aiichiro NagakiJun-ichi Yoshida
Jan 22, 2015·Angewandte Chemie·Christian BenzDetlev Belder
Feb 13, 2013·Chemistry, an Asian Journal·Aiichiro NagakiJun-ichi Yoshida
Jan 2, 2016·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·John J LewinGeoffrey Ling
Jan 29, 2019·Angewandte Chemie·Aiichiro NagakiJun-Ichi Yoshida
Feb 19, 2019·Chemistry : a European Journal·Aiichiro NagakiJun-Ichi Yoshida
Jun 29, 2011·Angewandte Chemie·Ryan L HartmanKlavs F Jensen
Aug 10, 2011·Chemical Society Reviews·Timothy Noël, Stephen L Buchwald
May 17, 2012·Organic & Biomolecular Chemistry·Shinichiro FuseTakashi Takahashi
Jul 25, 2014·Chemistry : a European Journal·Yuanhai SuTimothy Noël
Dec 7, 2018·Chemical & Pharmaceutical Bulletin·Takashi IkawaShuji Akai
Dec 25, 2013·Beilstein Journal of Organic Chemistry·Shinichiro FuseTakashi Takahashi

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Methods Mentioned

BETA
infrared spectroscopy
X-ray
nuclear magnetic resonance
electrophoresis
chip
NMR
acetylation

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