Integrated microRNA-mRNA analysis revealing the potential roles of microRNAs in tongue squamous cell cancer

Molecular Medicine Reports
Xiao-Li ZhouFu-Jun Guo

Abstract

Tongue squamous cell carcinoma (TSCC) is a rare and aggressive type of cancer, which is associated with a poor prognosis. Identification of patients at high risk of TSCC tumorigenesis may provide information for the early detection of metastases, and for potential treatment strategies. MicroRNA (miRNA; miR) and mRNA expression profiling of TSCC tissue samples and normal control tissue samples were obtained from three Gene Expression Omnibus (GEO) data series. Bioinformatics analyses, including the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes were used to identify genes and pathways specifically associated with miRNA-associated TSCC oncology. A total of 25 miRNAs and 769 mRNAs were differentially expressed in the two groups assessed, and all the differentially expressed miRNA and mRNA target interactions were analyzed. The miRNA target genes were predominantly associated with 38 GO terms and 13 pathways. Of the genes differentially expressed between the two groups, and confirmed in another GEO series, miRNA-494, miRNA-96, miRNA-183, runt-related transcription factor 1, programmed cell death protein 4 and membrane-associated guanylate kinase were the most significantly altered, and may be central in the regulati...Continue Reading

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Citations

Oct 6, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yang SunYoucheng Yu
Jul 26, 2018·Journal of Experimental & Clinical Cancer Research : CR·Yixue GuZhimin He
Jun 16, 2017·Clinical Oral Investigations·Gordana SupicZvonko Magic

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Datasets Mentioned

BETA
GSE9844
GSE13601

Software Mentioned

Pathway Analysis
TargetScan
Cluster
TargetScan Human
SPSS
Treeview
limma

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