Integrated-omics endotyping of infants with rhinovirus bronchiolitis and risk of childhood asthma.

The Journal of Allergy and Clinical Immunology
Yoshihiko RaitaKohei Hasegawa

Abstract

Young children with rhinovirus (RV) infection-particularly bronchiolitis-are at high risk for developing childhood asthma. Emerging evidence suggests clinical heterogeneity within RV bronchiolitis. However, little is known about these biologically distinct subgroups (endotypes) and their relations with asthma risk. We aimed to identify RV bronchiolitis endotypes and examine their longitudinal relations with asthma risk. As part of a multicenter prospective cohort study of infants (age <12 months) hospitalized for bronchiolitis, we integrated clinical, RV species (RV-A, RV-B, and RV-C), nasopharyngeal microbiome (16S rRNA gene sequencing), cytokine, and metabolome (liquid chromatography tandem mass spectrometry) data collected at hospitalization. We then applied network and clustering approaches to identify bronchiolitis endotypes. We also examined their longitudinal association with risks of developing recurrent wheeze by age 3 years and asthma by age 5 years. Of 122 infants hospitalized for RV bronchiolitis (median age, 4 months), we identified 4 distinct endotypes-mainly characterized by RV species, microbiome, and type 2 cytokine (T2) response: endotype A, virusRV-CmicrobiomemixedT2low; endotype B, virusRV-AmicrobiomeHaemoph...Continue Reading

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Citations

May 1, 2021·International Journal of Molecular Sciences·Chiao-Juno Chiu, Miao-Tzu Huang
Jun 14, 2021·The Journal of Allergy and Clinical Immunology·Zhaozhong ZhuKohei Hasegawa
Jan 3, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Kohei HasegawaCarlos A Camargo
Jun 19, 2021·The European Respiratory Journal·Jayanth Kumar NarayanaSanjay H Chotirmall
Sep 19, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Riku A ErkkolaTuomas Jartti

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