Integrated operation of continuous chromatography and biotransformations for the generic high yield production of fine chemicals

Journal of Biotechnology
Matthias BechtoldSven Panke

Abstract

The rapid progress in biocatalysis in the identification and development of enzymes over the last decade has enormously enlarged the chemical reaction space that can be addressed not only in research applications, but also on industrial scale. This enables us to consider even those groups of reactions that are very promising from a synthetic point of view, but suffer from drawbacks on process level, such as an unfavourable position of the reaction equilibrium. Prominent examples stem from the aldolase-catalyzed enantioselective carbon-carbon bond forming reactions, reactions catalyzed by isomerising enzymes, and reactions that are kinetically controlled. On the other hand, continuous chromatography concepts such as the simulating moving bed technology have matured and are increasingly realized on industrial scale for the efficient separation of difficult compound mixtures - including enantiomers - with unprecedented efficiency. We propose that coupling of enzyme reactor and continuous chromatography is a very suitable and potentially generic process concept to address the thermodynamic limitations of a host of promising biotransformations. This way, it should be possible to establish novel in situ product recovery processes of ...Continue Reading

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Citations

Aug 30, 2011·Applied Microbiology and Biotechnology·Chao HuCuiying Hu
May 12, 2009·New Biotechnology·Roland Wohlgemuth
Jan 17, 2016·Biotechnology Journal·Katarzyna WrzosekAndreas Seidel-Morgenstern
Sep 6, 2015·Journal of Chromatography. a·Rui P V Faria, Alírio E Rodrigues
Mar 21, 2015·Journal of Chromatography. a·Jani SiitonenTuomo Sainio
Jul 23, 2016·Applied Microbiology and Biotechnology·Christian FemmerSven Panke
May 20, 2008·Advances in Applied Microbiology·R E ParalesJ L Ditty
Jun 7, 2019·Biotechnology Journal·Nicole UlmerMassimo Morbidelli
Jan 21, 2014·Angewandte Chemie·Heike Lorenz, Andreas Seidel-Morgenstern
Jun 4, 2020·Biotechnology and Bioengineering·Christian FemmerSven Panke

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