Integrated phrenic responses to carotid afferent stimulation in adult rats following perinatal hyperoxia

The Journal of Physiology
L LingG S Mitchell

Abstract

1. Hypoxic ventilatory responses are greatly attenuated in adult rats exposed to moderate hyperoxia (60% O2) during the first month of life (perinatal treated rats). The present study was designed to test the hypothesis that perinatal hyperoxia impairs central integration of carotid chemoreceptor afferent inputs, thereby diminishing the hypoxic ventilatory response. 2. Time-dependent phrenic nerve responses to electrical stimulation of the carotid sinus nerve (CSN) and steady-state relationships between CSN stimulation frequency and phrenic nerve output were compared in control and perinatal treated rats. The rats were urethane anaesthetized, vagotomized, paralysed and artificially ventilated. End-tidal CO2 was monitored and maintained at isocapnic levels; arterial blood gases were determined. 3. Two stimulation protocols were used: (1) three 2 min episodes of CSN stimulation (20 Hz, 0.2 ms duration, 3 x threshold), separated by 5 min intervals; and (2) nine 45 s episodes of CSN stimulation with stimulus frequencies ranging from 0.5 to 20 Hz (0.2 ms duration, 3 x threshold), separated by 4 min intervals. 4. The mean threshold currents to elicit phrenic responses were similar between groups. Burst frequency (f, burst min-1), pea...Continue Reading

Citations

May 17, 2005·Respiratory Physiology & Neurobiology·Richard KinkeadAida Bairam
Mar 31, 2004·Seminars in Neonatology : SN·Estelle B GaudaDaniel Kwak
May 30, 2012·Respiratory Physiology & Neurobiology·Ryan W BavisElizabeth F Dmitrieff
May 23, 2012·Respiratory Physiology & Neurobiology·Andrea PorzionatoRaffaele De Caro
Sep 10, 2009·Biological Psychology·Richard Kinkead, Roumiana Gulemetova
Oct 8, 2015·Respiratory Physiology & Neurobiology·Sarah LoganRyan W Bavis
Aug 12, 2008·Respiratory Physiology & Neurobiology·P M MacFarlaneG S Mitchell
May 22, 2016·Experimental Neurology·David D Fuller, Gordon S Mitchell
Jun 2, 2016·Experimental Neurology·Ryan W Bavis, Peter M MacFarlane
Dec 18, 2003·The Journal of Physiology·J Prieto-LloretC Gonzalez
Apr 13, 2018·The Journal of Physiology·Andrea PorzionatoRaffaele De Caro
Dec 14, 2004·Journal of Applied Physiology·Michelle McGuire, Liming Ling
Jun 4, 2005·The Journal of Physiology·Michelle McGuireLiming Ling
Aug 10, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kirsten Szdzuy, Jacopo P Mortola
Mar 10, 2012·Journal of Applied Physiology·Nicole L NicholsGordon S Mitchell
Apr 16, 2010·Physiological Reviews·Luc J Teppema, Albert Dahan
Oct 23, 2002·Journal of Applied Physiology·Michelle McGuireLiming Ling
Oct 23, 2002·Journal of Applied Physiology·Ryan W Bavis, Gordon S Mitchell
Dec 18, 2002·Journal of Applied Physiology·John L Carroll
Dec 18, 2002·Journal of Applied Physiology·Gordon S Mitchell, Stephen M Johnson
Oct 11, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michelle McGuireLiming Ling
May 18, 2001·Journal of Applied Physiology·G S MitchellE B Olson
Feb 14, 2002·Journal of Applied Physiology·R W BavisG S Mitchell
Jul 18, 2001·Journal of Applied Physiology·E B OlsonG S Mitchel
Jun 24, 2003·Journal of Applied Physiology·Michelle McGuireLiming Ling
Sep 7, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·R KinkeadG S Mitchell

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