Integrated proteomics pipeline yields novel biomarkers for predicting preeclampsia

Hypertension
Jenny MyersRobyn A North

Abstract

Preeclampsia, a hypertensive pregnancy complication, is largely unpredictable in healthy nulliparous pregnant women. Accurate preeclampsia prediction in this population would transform antenatal care. To identify novel protein markers relevant to the prediction of preeclampsia, a 3-step mass spectrometric work flow was applied. On selection of candidate biomarkers, mostly from an unbiased discovery experiment (19 women), targeted quantitation was used to verify and validate candidate biomarkers in 2 independent cohorts from the SCOPE (SCreening fOr Pregnancy Endpoints) study. Candidate proteins were measured in plasma specimens collected at 19 to 21 weeks' gestation from 100 women who later developed preeclampsia and 200 women without preeclampsia recruited from Australia and New Zealand. Protein levels (n=25), age, and blood pressure were then analyzed using logistic regression to identify multimarker models (maximum 6 markers) that met predefined criteria: sensitivity ≥50% at 20% positive predictive value. These 44 algorithms were then tested in an independent European cohort (n=300) yielding 8 validated models. These 8 models detected 50% to 56% of preeclampsia cases in the training and validation sets; the detection rate fo...Continue Reading

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Citations

May 7, 2014·Biomarkers in Medicine·Melanie Griffin, Andrew H Shennan
Sep 23, 2014·Current Hypertension Reports·Anjali AcharyaTanvi Rege
Jan 11, 2014·Expert Review of Proteomics·Julie KleinJoost P Schanstra
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Mar 17, 2015·Expert Review of Molecular Diagnostics·Sinuhe HahnNandor Gabor Than
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Jun 13, 2015·Current Hypertension Reports·Rosanne J TurnerHans J Baelde
Feb 19, 2015·Biomarkers in Medicine·Wouter Laroy, Paul Ladestein
May 26, 2016·Current Hypertension Reports·Gemma Currie, Christian Delles
Jan 26, 2018·Journal of Hypertension·Alon BotzerRon Unger
Nov 25, 2017·Scientific Reports·Ray Bahado-SinghKypros Nicolaides
May 9, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Lina A Dahabiyeh
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