Integrated review of the association of cytokines with fibromyalgia and fibromyalgia core symptoms.

Biological Research for Nursing
Victoria Menzies, Debra E Lyon

Abstract

Fibromyalgia (FMS) is a chronic widespread pain (CWP) and fatigue syndrome that affects three to six million adults in the United States. Core symptoms of FMS include pain, fatigue, and mood and sleep disturbances. To date, consensus has not been reached among researchers regarding the pathogenesis of FMS nor the specific role of cytokine activation on the neuroendocrine-immune response patterns in persons with FMS. The purpose of this article is to describe and synthesize the results of research studies focused on the relationship between cytokines and FMS and among cytokines and core symptoms of FMS. There is some support in the literature for relationships among FMS symptoms and cytokines; however, there are discrepant findings related to whether proinflammatory and anti-inflammatory cytokines are elevated or reduced in persons with FMS and whether their levels correlate with the core symptoms of this disorder. Although the use of cytokine biomarkers must be considered exploratory at this time due to the lack of consistent empirical findings, biobehavioral research focused on understanding the relationship of FMS with cytokines may lead to a better understanding of this complex syndrome. This knowledge may ultimately contrib...Continue Reading

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Nov 1, 2011·BMC Musculoskeletal Disorders·Nurcan UçeylerClaudia Sommer
Dec 19, 2012·BMC Clinical Pathology·Frederick G BehmBruce S Gillis
Jun 25, 2014·Clinical Interventions in Aging·Marta ImamuraLinamara Rizzo Battistella
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