Integrated sphingosine-1 phosphate signaling in the central nervous system: From physiological equilibrium to pathological damage

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Rasoul GhasemiAbolhassan Ahmadiani

Abstract

Sphingosine-1 phosphate (S1P), a bioactive sphingolipid metabolite, plays an essential role in cellular homeostasis. It is well evidenced that enzymes responsible for S1P production, as well as S1P receptors are expressed in the central nervous system (CNS), implying that S1P may contribute to CNS physiology. In current review, we will present the current knowledge about developmental and neuromodulatory functions of S1P in the brain. Considering neuroprotective effects of S1P, we also review the relation between S1P and cellular autophagy, mitochondrial function, oxidative stress and apoptosis as well as molecular pathways underlying neuroprotective effects of S1P. Given these pivotal functions, in the last section, we will summarize latest findings about possible contribution of S1P dysregulation in neurological disorders like Alzheimer's disease and multiple sclerosis.

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Jul 10, 2016·Neuromolecular Medicine·Mitchell K P LaiDeron R Herr
Aug 3, 2016·Medicinal Research Reviews·Dominik Vogt, Holger Stark
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Dec 22, 2019·International Journal of Molecular Sciences·Elisabetta Meacci, Mercedes Garcia-Gil
Jul 15, 2018·Nature Communications·Brunilde GrilPatricia S Steeg

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