Integrated texture parameter of 18F-FDG PET may be a stratification factor for the survival of nonoperative patients with locally advanced non-small-cell lung cancer

Nuclear Medicine Communications
Wenju LiuShuanghu Yuan

Abstract

This study explored whether integrated texture parameter (ITP) of the fluorine-18-fluorodeoxyglucose PET (F-FDG PET) is a stratification factor for the survival of nonoperative patients with locally advanced non-small-cell lung cancer (LA-NSCLC). Thirty-five patients with LA-NSCLC treated with chemoradiotherapy or radiotherapy were included in the retrospective study. Eight principal components (PCs) were extracted from 72 F-FDG PET texture features (TFs) using PC analysis. The survival rates between PC subgroups (group by median value) were compared using Kaplan-Meier method. Seventy-two factor loadings for PC7 were evaluated using t-test. Standardized values of the TFs with significant factor loading were multiplied by the corresponding PC7 component coefficient, and the products were added together to obtain ITP. The survival rates between ITP subgroups (group by median value) were compared using Kaplan-Meier method. Patient characteristics between ITP subgroups were compared using χ -test, Mann-Whitney U-test, or t-test. The median follow-up time was 20.7 months. The median overall survival (OS) and progression-free survival (PFS) were 32.5 and 14.4 months, respectively. The patients with high PC7 value had lesser OS (P=0.0...Continue Reading

References

Feb 28, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A AupérinUNKNOWN Meta-Analysis of Cisplatin/carboplatin based Concomitant Chemotherapy in non-small cell Lung Cancer (MAC3-LC) Group
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne AupérinJean-Pierre Pignon
Oct 16, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Sugama ChickloreGary J R Cook
Dec 4, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gary J R CookDavid Landau
Jun 7, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Florent TixierCatherine Cheze Le Rest
May 6, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hao ZhangYonglin Pu
Jun 17, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Zachary A KohutekAndreas Rimner
Feb 3, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Pierre LovinfosseRoland Hustinx
Feb 21, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Marie-Charlotte DesseroitMathieu Hatt
Feb 26, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nitin OhriIssam El Naqa
Mar 15, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Anne Winther-LarsenPeter Meldgaard
Sep 8, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Evelyn E C de JongAnne-Marie C Dingemans
Oct 16, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Roelof J BeukingaJohn Th M Plukker
Dec 15, 2016·The Annals of Thoracic Surgery·Aritoshi HattoriKenji Suzuki
Mar 25, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Edwin A UsmanijLioe-Fee de Geus-Oei

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Citations

Mar 7, 2021·Diagnostics·Manuel Piñeiro-FielPablo Aguiar
Oct 24, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Gargi KothariShankar Siva

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Software Mentioned

SPSS
Xeleris
Chang image texture analysis ( CGITA )
CGITA

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