Integrating bioinformatics and clinicopathological research of gastrointestinal stromal tumors: identification of aurora kinase A as a poor risk marker

Annals of Surgical Oncology
Chueh-Chuan YenJonathan A Fletcher

Abstract

For completely resected primary gastrointestinal stromal tumors (GISTs), mitotic rate, tumor size, and tumor location are important risk factors for recurrence. However, molecular markers for recurrence are still lacking. We reanalyzed GIST gene expression profile GSE8167 available from the Gene Expression Omnibus (GEO) and confirmed the prognostic influence of one selected gene, aurora kinase A (AURKA), in another cohort of 142 patients using immunohistochemistry (IHC). Thirty-two cases in GSE8167 were classified into two risk groups with distinct recurrence-free survival (RFS) and expression profiles using modified criteria of Miettinen et al. from the Armed Forces Institute of Pathology (AFIP-Miettinen). AURKA was among the 19 genes common to the top 50 features of the high-risk phenotype and a 67-gene signature called the complexity index in sarcomas. AURKA was significantly overexpressed in the high-risk group, and patients with high AURKA expression had significantly worse RFS than those with low expression. In the IHC-validated cohort, AURKA expression was significantly higher in nongastric tumors than in gastric tumors and was significantly correlated with AFIP-Miettinen risk group. Univariate analysis showed that RFS w...Continue Reading

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Citations

Sep 30, 2014·Journal of Medical Case Reports·Suzana Manxhuka-KerliuVesa Kotorri
Oct 8, 2013·Hematology/oncology Clinics of North America·Heikki Joensuu
Jan 28, 2015·International Journal of Oncology·Kiyoko UmeneDaisuke Aoki
Aug 22, 2018·Oncology Letters·Jen-Shi ChenYee Chao
Sep 6, 2019·International Journal of Oncology·Chueh-Chuan YenWei-Ming Chen
Jul 14, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·X Liu, K-M Chu
Nov 19, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vikas SehdevWael El-Rifai

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