Integrating biomarkers into clinical decision making for colorectal cancer

Clinical Colorectal Cancer
Peter M Wilson, Heinz-Josef Lenz

Abstract

The advent of pharmacogenetics and its underlying concept that disparities in drug metabolism, efficacy, and toxicity are determined by the genetic makeup of an individual has birthed the concept and promise of 'tailored medicine.' One such facet of medicine that serves to benefit greatly from this tailored approach is the implementation of chemotherapy in cancer treatment. The past decade has witnessed significant advances in the treatment of colorectal cancer (CRC); however, tumor drug resistance remains a major obstacle in CRC treatment, and many patients do not receive any clinical benefit from chemotherapy. In addition, a significant patient population will experience adverse reactions to treatment, resulting in dose reductions or chemotherapy withdrawal, which can severely affect treatment efficacy. In light of these considerable challenges, significant research efforts are currently under way to identify reliable and validated biomarkers with the power to guide the clinician in deciding when to implement chemotherapy and which strategy is likely to have the greatest clinical impact with minimal toxicities. However, current biomarkers for CRC are few, and the search for reliable biomarkers has turned out to be more challe...Continue Reading

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Citations

Dec 3, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Marko KornmannKarl-Heinrich Link

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