Integrating Brain and Biomechanical Models-A New Paradigm for Understanding Neuro-muscular Control

Frontiers in Neuroscience
Sebastian S JamesKevin N Gurney

Abstract

To date, realistic models of how the central nervous system governs behavior have been restricted in scope to the brain, brainstem or spinal column, as if these existed as disembodied organs. Further, the model is often exercised in relation to anin vivophysiological experiment with input comprising an impulse, a periodic signal or constant activation, and output as a pattern of neural activity in one or more neural populations. Any link to behavior is inferred only indirectly via these activity patterns. We argue that to discover the principles of operation of neural systems, it is necessary to express their behavior in terms of physical movements of a realistic motor system, and to supply inputs that mimic sensory experience. To do this with confidence, we must connect our brain models to neuro-muscular models and provide relevant visual and proprioceptive feedback signals, thereby closing the loop of the simulation. This paper describes an effort to develop just such an integrated brain and biomechanical system using a number of pre-existing models. It describes a model of the saccadic oculomotor system incorporating a neuromuscular model of the eye and its six extraocular muscles. The position of the eye determines how illu...Continue Reading

References

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Citations

May 16, 2019·BMC Research Notes·Keneth Iceland KasoziMuhamudu Kalange

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Methods Mentioned

BETA
feature extraction

Software Mentioned

MATLAB
SC
TModel4
OpenSim
_ BRAHMS
LINlinear
GeNN
SpineCreator
worldDataMaker
deep

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