Integrating Circulating Immunological and Sputum Biomarkers for the Early Detection of Lung Cancer

Biomarkers in Cancer
Jian SuFeng Jiang

Abstract

We have demonstrated that assessments of microRNA (miRNA) expressions in circulating peripheral blood mononucleated cell (PBMC) and sputum specimens, respectively, may help diagnose lung cancer. To assess the individual and combined analysis of the miRNAs across the different body fluids for lung cancer early detection, we analyse a panel of 3 sputum miRNAs (miRs-21, 31, and 210) and a panel of 2 PBMC miRNAs (miRs-19b-3p and 29b-3p) in a discovery cohort of 68 patients with lung cancer and 66 cancer-free smokers. We find that integrating 2 sputum miRNAs (miRs-31 and 210) and 1 PBMC miRNA (miR-19b-3p) has higher sensitivity (86.8%) and specificity (92.4%) compared with the individual panels. The synergistic value of the integrated panel of 3 biomarkers is confirmed in a validation cohort, independent of stage and histological type of lung cancer, and patients' age, sex, and ethnicity. Integrating circulating immunological and sputum biomarkers could improve the early detection of lung cancer.

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Citations

Nov 13, 2018·Journal of Cancer Research and Clinical Oncology·Tingting GuoPeng Gao
Feb 15, 2020·International Journal of Molecular Sciences·Xing-Ning LaiLi-Xia Xiong
Mar 7, 2021·Diagnostics·Qixin LengFeng Jiang
May 6, 2021·Journal of Personalized Medicine·Ning LiFeng Jiang

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