Integrating clinical indexes into four-diagnostic information contributes to the Traditional Chinese Medicine (TCM) syndrome diagnosis of chronic hepatitis B

Scientific Reports
Hong KangZhiwei Cao

Abstract

Traditional Chinese Medicine (TCM) treatment has been commonly used to treat Chronic Hepatitis B (CHB) in Asian countries based on TCM syndrome diagnosis, also called "ZHENG". The syndrome is identified through the four-diagnostic methods, with certain degree of subjectivity and ambiguity from individual doctors. Normally those CHB patients also receive series of parameters from modern clinical examination, while they are routinely believed to be unrelated with the TCM syndrome diagnosis. In this study, we investigated whether these biomedical indexes in modern medicine could be beneficial to TCM syndrome diagnostics in an integrative way. Based on 634 patient samples from health controls and three subtypes of CHB syndromes, a two-view based hierarchical classification model was tested for TCM syndromes prediction based on totally 222 parameters integrated from both TCM practice and modern clinical tests. The results indicated that the performance of syndrome classification based on a proper integration of TCM and modern clinical indexes was significantly higher than those based on one view of parameters only. Furthermore, those indexes correlated with CHB syndrome diagnosis were successfully identified for CM indexes and bioch...Continue Reading

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Citations

Oct 28, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Yine HuWenchao Tang
Oct 18, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·X T LiJ E Chaplin
Jul 30, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Shujie XiaCandong Li
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Feb 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shu-Jie XiaYu-Dong Zhang
May 15, 2021·Journal of Healthcare Engineering·Qiuping LiBing Zhou

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