Integrating clinical metabolomics-based biomarker discovery and clinical pharmacology to enable precision medicine

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Isabelle KohlerJ G Coen van Hasselt

Abstract

Novel developments in biomarkers discovery are essential in modern health care, notably in treatment individualization and precision medicine. Clinical metabolomics, which aims to identify small molecule metabolites present in patient-derived samples, has attracted much attention to support discovery of novel biomarkers. However, the step from discriminatory features of disease states towards biomarkers that can truly individualize treatments is challenging. Biomarkers used for treatment individualization can either be dynamic or static prognostic biomarkers. Dynamic biomarkers are relevant for describing the clinical response, including dynamical disease progression and associated treatment response. Static (prognostic) biomarkers do not describe but rather predict a clinical response, and typically reflect aspects of the physiological state of a patient related to drug treatment response or disease progression dynamics. Pharmacokinetic-pharmacodynamic (PK-PD) modeling represents an established approach for drug treatment individualization based on drug exposure or treatment response biomarkers, as well as for the description of disease progression dynamics. Here, we discuss how novel treatment individualization biomarkers can...Continue Reading

References


❮ Previous
Next ❯

Citations

May 17, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sebastiaan C GouloozeJ G Coen van Hasselt
Sep 28, 2018·Annual Review of Pharmacology and Toxicology·J G Coen van Hasselt, Ravi Iyengar
Feb 15, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jia-Lei TaoBin Yuan
Feb 17, 2018·Pharmaceutical Research·Willem Johan van den BrinkElizabeth Cunera Maria de Lange
Nov 30, 2019·Metabolites·Dimitris TsoukalasAristides Tsatsakis
Mar 10, 2018·Expert Opinion on Drug Discovery·W J van den BrinkE C M de Lange
Jan 27, 2019·CPT: Pharmacometrics & Systems Pharmacology·Willem J van den BrinkElizabeth C M de Lange
Dec 20, 2018·The AAPS Journal·Sebastiaan C GouloozeCatherijne A J Knibbe
Nov 19, 2019·Frontiers in Molecular Biosciences·Dimitris TsoukalasDaniela Calina
Dec 18, 2020·British Journal of Clinical Pharmacology·Nicholas P GiangrecoNicholas P Tatonetti
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ksenia M ShestakovaSvetlana A Appolonova
Feb 20, 2021·The Analyst·Eulalia OlestiSerge Rudaz
Feb 25, 2021·Journal of Gastroenterology and Hepatology·Chen-Ya Kuo, Han-Mo Chiu
Nov 1, 2018·Analytical Chemistry·Xiaoling ZangFacundo M Fernández
Aug 26, 2021·Analytical and Bioanalytical Chemistry·Florence Anne CastelliChristophe Junot
Oct 6, 2017·ACS Chemical Neuroscience·Meng QiJonathan V Sweedler
Aug 8, 2021·British Journal of Pharmacology·Gaëlle MaglioccoYoussef Daali
Oct 4, 2021·The FEBS Journal·Emily M Schleicher, George-Lucian Moldovan
Nov 23, 2021·Analytical Chemistry·Ana M SalmerónIgnacio Fernández

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved