Integrating farm and air pollution studies in search for immunoregulatory mechanisms operating in protective and high-risk environments

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Maria-Viola MartikainenM Roponen

Abstract

Studies conducted in farm environments suggest that diverse microbial exposure promotes children's lung health. The underlying mechanisms are unclear, and the development of asthma-preventive strategies has been delayed. More comprehensive investigation of the environment-induced immunoregulation is required for better understanding of asthma pathogenesis and prevention. Exposure to air pollution, including particulate matter (PM), is a risk factor for asthma, thus providing an excellent counterpoint for the farm-effect research. Lack of comparable data, however, complicates interpretation of the existing information. We aimed to explore the immunoregulatory effects of cattle farm dust (protective, Finland) and urban air PM (high-risk, China) for the first time using identical research methods. We stimulated PBMCs of 4-year-old children (N = 18) with farm dust and size-segregated PM and assessed the expression of immune receptors CD80 and ILT4 on dendritic cells and monocytes as well as cytokine production of PBMCs. Environmental samples were analysed for their composition. Farm dust increased the percentage of cells expressing CD80 and the cytokine production of children's immune cells, whereas PM inhibited the expression of i...Continue Reading

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Citations

Aug 20, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe Eigenmann
Sep 17, 2020·Allergy, Asthma & Immunology Research·Xinliu LinJing Li
Apr 18, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe Eigenmann
Oct 1, 2019·Current Opinion in Pulmonary Medicine·Ariangela Kozik, Yvonne J Huang
May 5, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe Eigenmann
Feb 3, 2021·Dermatologic Therapy·Ruhollah AbolhasaniReza M Robati
Jun 25, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Maria-Viola MartikainenMarjut Roponen
Aug 21, 2021·European Journal of Immunology·Julie DeckersErika von Mutius
Aug 30, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Johanna TheodorouBianca Schaub

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