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Integrating functional data to prioritize causal variants in statistical fine-mapping studies

PLoS Genetics

Oct 31, 2014

Gleb KichaevBogdan Pasaniuc

Abstract

Standard statistical approaches for prioritization of variants for functional testing in fine-mapping studies either use marginal association statistics or estimate posterior probabilities for variants to be causal under simplifying assumptions. Here, we present a probabilistic framewor...read more

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Genome-Wide Association Study
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Deoxyribonuclease I
Low Density Lipoprotein Cholesterol Measurement
Exons
Genome
Transcription Initiation Site
Aggregation
Total cholesterol
34
1
299
Paper Details
References
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  • References36
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Integrating functional data to prioritize causal variants in statistical fine-mapping studies

PLoS Genetics

Oct 31, 2014

Gleb KichaevBogdan Pasaniuc

PMID: 25357204

DOI: 10.1371/journal.pgen.1004722

Abstract

Standard statistical approaches for prioritization of variants for functional testing in fine-mapping studies either use marginal association statistics or estimate posterior probabilities for variants to be causal under simplifying assumptions. Here, we present a probabilistic framewor...read more

Mentioned in this Paper

Establishment and Maintenance of Localization
Genome-Wide Association Study
Meta-Analysis (Publications)
Deoxyribonuclease I
Low Density Lipoprotein Cholesterol Measurement
Exons
Genome
Transcription Initiation Site
Aggregation
Total cholesterol
34
1
299

Similar Papers Found In These Feeds

Neuroscience: Genomics

Neuroscience integrates data from anatomical, biological, developmental, and mathematical models to understand the nervous system. Here is the latest research on genomics in neuroscience.

Open Access Genomics Journals

Discover the latest genomics research in this collection of the top open access genomics journals.

Related Papers

Paper Details
References
  • References36
  • Citations84
1234
  • References36
  • Citations84
12345...
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