Integrating Genetic and Genomic Analyses of Combined Health Data Across Ecotypes to Improve Disease Resistance in Indigenous African Chickens

Frontiers in Genetics
Georgios BanosAndroniki Psifidi

Abstract

Poultry play an important role in the agriculture of many African countries. The majority of chickens in sub-Saharan Africa are indigenous, raised in villages under semi-scavenging conditions. Vaccinations and biosecurity measures rarely apply, and infectious diseases remain a major cause of mortality and reduced productivity. Genomic selection for disease resistance offers a potentially sustainable solution but this requires sufficient numbers of individual birds with genomic and phenotypic data, which is often a challenge to collect in the small populations of indigenous chicken ecotypes. The use of information across-ecotypes presents an attractive possibility to increase the relevant numbers and the accuracy of genomic selection. In this study, we performed a joint analysis of two distinct Ethiopian indigenous chicken ecotypes to investigate the genomic architecture of important health and productivity traits and explore the feasibility of conducting genomic selection across-ecotype. Phenotypic traits considered were antibody response to Infectious Bursal Disease (IBDV), Marek's Disease (MDV), Fowl Cholera (PM) and Fowl Typhoid (SG), resistance to Eimeria and cestode parasitism, and productivity [body weight and body condit...Continue Reading

References

Feb 26, 2004·Tropical Animal Health and Production·M K HassanM M Aly
Dec 31, 2005·Nucleic Acids Research·A S HinrichsW J Kent
Sep 24, 2009·Biochemistry·Minyong ChenWei Chen
May 11, 2010·Journal of Applied Genetics·Q-H NieX-Q Zhang
Jul 14, 2010·Tropical Animal Health and Production·Nigussie DanaJohan A M van Arendonk
Jan 30, 2013·BMC Genomics·Andreas KranisDavid W Burt
Dec 18, 2013·Bioinformatics·Andreas KrämerStuart Tugendreich
Mar 1, 2014·Genetics, Selection, Evolution : GSE·Haroldo H R NevesJosé Fernando Garcia
Aug 3, 2014·Preventive Veterinary Medicine·J M BettridgeR M Christley
Apr 22, 2015·Nucleic Acids Research·Damian SmedleyArek Kasprzyk
Sep 19, 2015·Genetics, Selection, Evolution : GSE·Rianne van BinsbergenRoel F Veerkamp
Feb 21, 2016·Genetics, Selection, Evolution : GSE·Oscar O M IheshiulorTheo H E Meuwissen
Jun 9, 2016·Genome Biology·William McLarenFiona Cunningham
Oct 1, 2016·Genetics, Selection, Evolution : GSE·Androniki PsifidiPete Kaiser
Jan 17, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Chongyuan ZhangPing Hu
May 22, 2017·Journal of Dairy Science·S A BoisonM V G B da Silva
Oct 7, 2017·Parasitology Research·Lysanne HiobB Bangoura
Nov 10, 2018·Nature Sustainability·Judy M BettridgeRobert M Christley
Nov 5, 2019·Frontiers in Cell and Developmental Biology·Sweta SwetaRaghu Bhushan

❮ Previous
Next ❯

Citations

Sep 4, 2021·Veterinary World·Adil Sabr Al-Ogaili, Samer Sadeq Hameed

❮ Previous
Next ❯

Datasets Mentioned

BETA
SRP142580

Methods Mentioned

BETA
ELISA
genotyping

Software Mentioned

Ensembl
UCSC liftOver
BWA
Ingenuity Pathway Analysis ( IPA )
BioMart
PLINK
GATK
MEM
IPA
Affymetrix

Related Concepts