Integrating human and rodent data to identify the genetic factors involved in chronic kidney disease.

Journal of the American Society of Nephrology : JASN
Michael R GarrettRon Korstanje

Abstract

The increasing numbers of patients with chronic kidney disease combined with no satisfying interventions for preventing or curing the disease emphasize the need to better understand the genes involved in the initiation and progression of complex renal diseases, their interactions with other host genes, and the environment. Linkage and association studies in human, rat, and mouse have been successful in identifying genetic loci for various disease-related phenotypes but have thus far not been very successful identifying underlying genes. The purpose of this review is to summarize the progress in human, rat, and mouse genetic studies to show the concordance between the loci among the different species. The collective utilization of human and nonhuman mammalian datasets and resources can lead to a more rapid narrowing of disease loci and the subsequent identification of candidate genes. In addition, genes identified through these methods can be further characterized and investigated for interactions using animal models, which is not possible in humans.

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Citations

Mar 18, 2011·ILAR Journal·Rong YuanBeverly Paigen
Aug 4, 2012·American Journal of Physiology. Renal Physiology·Jill ThaiszKeith Dipetrillo
Dec 25, 2010·Journal of the American Society of Nephrology : JASN·Denise LaouariFabiola Terzi
Oct 30, 2010·Journal of the American Society of Nephrology : JASN·Rachael S HagemanRon Korstanje
May 10, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Rong YuanDavid E Harrison
Mar 1, 2013·Kidney International·David A LongAdrian S Woolf
Jul 30, 2015·Aging Cell·Gerda A NoordmansRon Korstanje
Feb 4, 2011·Journal of the American Society of Nephrology : JASN·Raymond C Harris
Jan 9, 2015·Journal of the American Society of Nephrology : JASN·Elena LazzeriPaola Romagnani
May 5, 2020·Trends in Genetics : TIG·Michael R Garrett, Ron Korstanje

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