Integrating MRI-based geometry, composition and fiber architecture in a finite element model of the human intervertebral disc.

Journal of the Mechanical Behavior of Biomedical Materials
Marc A StadelmannPhilippe K Zysset

Abstract

Intervertebral disc degeneration is a common disease that is often related to impaired mechanical function, herniations and chronic back pain. The degenerative process induces alterations of the disc's shape, composition and structure that can be visualized in vivo using magnetic resonance imaging (MRI). Numerical tools such as finite element analysis (FEA) have the potential to relate MRI-based information to the altered mechanical behavior of the disc. However, in terms of geometry, composition and fiber architecture, current FE models rely on observations made on healthy discs and might therefore not be well suited to study the degeneration process. To address the issue, we propose a new, more realistic FE methodology based on diffusion tensor imaging (DTI). For this study, a human disc joint was imaged in a high-field MR scanner with proton-density weighted (PD) and DTI sequences. The PD image was segmented and an anatomy-specific mesh was generated. Assuming accordance between local principal diffusion direction and local mean collagen fiber alignment, corresponding fiber angles were assigned to each element. Those element-wise fiber directions and PD intensities allowed the homogenized model to smoothly account for compos...Continue Reading

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Dec 3, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Ghislain MaquerPhilippe K Zysset

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Citations

Jul 20, 2019·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Yongtao LuYongxuan Wang
Jun 17, 2020·Computer Methods in Biomechanics and Biomedical Engineering·Marc A StadelmannPhilippe K Zysset
Apr 14, 2019·Biomechanics and Modeling in Mechanobiology·Arthur J Michalek
Jan 17, 2021·Acta Biomaterialia·Farshid GhezelbashJohn J Costi
Feb 7, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Leonardo MolinariAlberto Di Martino
Jun 15, 2021·Frontiers in Bioengineering and Biotechnology·Marlène MengoniRuth K Wilcox
Jul 6, 2021·Frontiers in Bioengineering and Biotechnology·Yuekang DuNicolas Newell
Aug 9, 2021·Journal of the Mechanical Behavior of Biomedical Materials·A R DixonR K Wilcox

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