Integrating novel technologies to fabricate smart scaffolds

Journal of Biomaterials Science. Polymer Edition
Lorenzo MoroniClemens A Van Blitterswijk

Abstract

Tissue engineering aims at restoring or regenerating a damaged tissue by combining cells, derived from a patient biopsy, with a 3D porous matrix functioning as a scaffold. After isolation and eventual in vitro expansion, cells are seeded on the 3D scaffolds and implanted directly or at a later stage in the patient's body. 3D scaffolds need to satisfy a number of requirements: (i) biocompatibility, (ii) biodegradability and/or bioresorbability, (iii) suitable mechanical properties, (iv) adequate physicochemical properties to direct cell-material interactions matching the tissue to be replaced and (v) ease in regaining the original shape of the damaged tissue and the integration with the surrounding environment. Still, it appears to be a challenge to satisfy all the aforementioned requisites with the biomaterials and the scaffold fabrication technologies nowadays available. 3D scaffolds can be fabricated with various techniques, among which rapid prototyping and electrospinning seem to be the most promising. Rapid prototyping technologies allow manufacturing scaffolds with a controlled, completely accessible pore network--determinant for nutrient supply and diffusion--in a CAD/CAM fashion. Electrospinning (ESP) allows mimicking t...Continue Reading

References

May 1, 1991·Journal of Biomechanical Engineering·L G CimaR Langer
May 1, 1991·Journal of Biomechanical Engineering·E BellC Nolte
Jan 1, 1990·Biomaterials, Artificial Cells, and Artificial Organs·T Chandy, C P Sharma
Jan 1, 1988·Journal of Pediatric Surgery·J P VacantiR Langer
Sep 1, 1986·Biomaterials·K W LeongR Langer
Jul 1, 1980·Journal of Biomedical Materials Research·N DagalakisI V Yannas
Jul 1, 1994·Bio/technology·L E FreedR Langer
Oct 1, 1994·Journal of Cellular Biochemistry·I V Yannas
Jan 1, 1994·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·R J Crawford, G N Askin
May 1, 1994·Journal of Biomedical Materials Research·G J BeumerM Ponec
Jan 1, 1993·Journal of Biomedical Materials Research·L E FreedR Langer
Feb 1, 1993·Journal of Biomedical Materials Research·A G MikosR Langer
Jan 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E M Lau, C Cooper
May 14, 1993·Science·R Langer, J P Vacanti
Jan 1, 1996·Journal of Biomedical Materials Research·J M Pachence
Apr 1, 1996·Journal of Biomedical Materials Research·H LoK W Leong
Jan 1, 1996·Journal of Biomaterials Science. Polymer Edition·R A GiordanoM J Cima
Nov 1, 1996·The Journal of Bone and Joint Surgery. British Volume·S K BulstraA J van der Linden
Mar 1, 1997·Neurosurgery·A Sanan, S J Haines
Apr 1, 1997·Biomaterials·L Shapiro, S Cohen
Jul 1, 1997·Clinical Orthopaedics and Related Research·C R ChuD Amiel
Mar 21, 1998·Transplant Immunology·L E Niklason, R S Langer
Mar 24, 1998·Journal of Biomedical Materials Research·T G van KootenA von Recum
Jun 5, 1998·Biomaterials·A Curtis, C Wilkinson
Jun 11, 1998·Trends in Biotechnology·B S Kim, D J Mooney
Jun 25, 1998·Journal of Biomedical Materials Research·B S Kim, D J Mooney
Oct 17, 1998·Journal of Biomedical Materials Research·J AignerA Naumann
Jan 12, 1999·Biomaterials·D CampocciaD F Williams
Feb 11, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·J M Anderson, J J Langone
Apr 23, 1999·Biomaterials·R G FlemmingP F Nealey
May 7, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·W Y Chen, G Abatangelo
Jun 26, 1999·Biomaterials·S V Madihally, H W Matthew
Jul 23, 1999·Annals of the New York Academy of Sciences·K E HealyR A Stile

❮ Previous
Next ❯

Citations

Oct 21, 2009·Journal of Materials Science. Materials in Medicine·Ana Rita C DuarteRui L Reis
Sep 10, 2011·Tissue Engineering. Part B, Reviews·Scott J Hollister, William L Murphy
Aug 23, 2011·Tissue Engineering. Part C, Methods·Natalja E FedorovichWouter J A Dhert
Oct 30, 2009·Journal of the Royal Society, Interface·Viviana Mouriño, Aldo R Boccaccini
May 15, 2009·Regenerative Medicine·Guoming Sun, Sharon Gerecht
Dec 31, 2009·World Journal of Stem Cells·Brigitte AltmannEric Gottwald
Jan 1, 2014·Journal of Clinical Medicine·Patrick BabczykEdda Tobiasch
Apr 25, 2012·Annual Review of Biomedical Engineering·Andrés Díaz Lantada, Pilar Lafont Morgado
Dec 1, 2012·Biotechnology Advances·Ali TamayolDavid Juncker
Mar 29, 2014·Journal of Materials Science. Materials in Medicine·Miguel A Mateos-TimonedaElisabeth Engel
Oct 31, 2013·Tissue Engineering. Part B, Reviews·Xiang-Zhen YanFang Yang
May 27, 2014·Biotechnology Advances·Lara Yildirimer, Alexander M Seifalian
Apr 9, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jianwen Xu, Jie Song
Jan 23, 2013·Trends in Biotechnology·Eelco FennemaJan de Boer
Mar 22, 2012·Advanced Drug Delivery Reviews·G PagniW V Giannobile
Mar 9, 2010·Biochemical and Biophysical Research Communications·Zufu Lu, Hala Zreiqat
Dec 9, 2009·Biomaterials·Sergey V Dorozhkin
Jan 7, 2010·Acta Biomaterialia·Bernke J PapenburgDimitrios Stamatialis
May 19, 2009·Acta Biomaterialia·Shalu Suri, Christine E Schmidt
Sep 12, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Alexander HoppeAldo R Boccaccini
Mar 27, 2015·Journal of Biomedical Materials Research. Part a·Marianne ParentCaroline Gaucher
Jun 17, 2009·Journal of Tissue Engineering and Regenerative Medicine·H M AydinY Yang
Nov 26, 2010·Journal of Cellular and Molecular Medicine·Dorothee KlumppJustus P Beier
Apr 11, 2012·Journal of Biomedical Materials Research. Part a·E BerneelM Cornelissen
Sep 3, 2011·Journal of Biomedical Materials Research. Part a·Decheng MengAldo R Boccaccini
Jul 10, 2013·Journal of Oral Rehabilitation·C JakobsenT H Thygesen
Mar 29, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Dario PuppiEmo Chiellini
Dec 17, 2009·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Hua XuSong-Tao Ai
Aug 18, 2009·Journal of Tissue Engineering and Regenerative Medicine·Chiming YangHelen M Burt
Jan 20, 2011·Biophysical Journal·M EhrbarM P Lutolf
Jul 3, 2015·Acta Biomaterialia·S M GiannitelliA Rainer
Oct 24, 2014·Tissue Engineering. Part B, Reviews·M Lourdes Muerza-CascantePaul D Dalton
Mar 17, 2015·Advanced Healthcare Materials·Giselle C YeoAnthony S Weiss
Dec 17, 2015·Advanced Healthcare Materials·Sunny A AbbahDimitrios I Zeugolis
Jun 18, 2011·Journal of Biomaterials Applications·Anca-Dana BendreaIoan Cianga

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.