PMID: 11567876Sep 25, 2001

Integrating stress-response and cell-cycle checkpoint pathways

Trends in Cell Biology
A K Pearce, T C Humphrey


The DNA integrity checkpoint and stress kinase (SAPK/JNK and p38) pathways function to modulate cell-cycle, apoptotic and transcriptional responses to stress. Although initially considered to function independently, recent advances indicate a number of links between the stress-response and checkpoint pathways. Here, we consider the relationship between the stress-response and checkpoint pathways and how they interact to modulate cell-cycle control.


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Related Concepts

Biochemical Pathway
Apoptosis, Intrinsic Pathway
Transcription, Genetic
Oxidative Stress
Cell Cycle
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DNA Replication
DNA Integrity Checkpoint
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