Integrating the DNA damage and protein stress responses during cancer development and treatment

The Journal of Pathology
Vassilis G GorgoulisIoannis P Trougakos

Abstract

During evolution, cells have developed a wide spectrum of stress response modules to ensure homeostasis. The genome and proteome damage response pathways constitute the pillars of this interwoven 'defensive' network. Consequently, the deregulation of these pathways correlates with ageing and various pathophysiological states, including cancer. In the present review, we highlight: (1) the structure of the genome and proteome damage response pathways; (2) their functional crosstalk; and (3) the conditions under which they predispose to cancer. Within this context, we emphasize the role of oncogene-induced DNA damage as a driving force that shapes the cellular landscape for the emergence of the various hallmarks of cancer. We also discuss potential means to exploit key cancer-related alterations of the genome and proteome damage response pathways in order to develop novel efficient therapeutic modalities. © 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

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Citations

Sep 29, 2018·International Journal of Molecular Sciences·Marios KritsilisDimitrios Papadopoulos
Dec 28, 2019·Cancers·Nikolaos AntoniouVassilis G Gorgoulis
Jul 10, 2019·Cells·Panagiotis V S VasileiouSophia Havaki
Aug 11, 2020·International Journal of Radiation Biology·Jingya LiuLi Chang
Jul 18, 2020·Cell Death & Disease·Josephine Ann Mun Yee ChooMatthias Dobbelstein
Sep 27, 2020·Cells·Gisela Machado-OliveiraOtília V Vieira
Sep 26, 2020·Cell Death & Disease·Qianzhi ChenYongdong Feng
Aug 18, 2018·Journal of Immunology Research·Martha Paola Mireles-CanalesCésar Pacheco-Tena
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Jan 11, 2021·Mechanisms of Ageing and Development·Eugenia RoupakiaEvangelos Kolettas
Nov 12, 2020·Cancers·Zacharenia NikitakiAlexandros G Georgakilas
Dec 4, 2020·International Journal of Molecular Sciences·Janusz BlasiakKai Kaarniranta
Apr 4, 2021·Cancers·Daniele CaraccioloPierfrancesco Tassone
Apr 4, 2021·International Journal of Molecular Sciences·Małgorzata Grzanka, Agnieszka Piekiełko-Witkowska
Apr 16, 2021·Frontiers in Cell and Developmental Biology·Ruchi Kumari, Parmjit Jat
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Dec 2, 2020·Journal of Natural Products·Hyo-Moon ChoWon-Keun Oh
Jan 15, 2022·Pharmaceutical Research·Md Nurul Huda, Md Nurunnabi

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Methods Mentioned

BETA
electron microscopy
ubiquitination

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