Abstract
Gastroschisis is a malformation with an unknown aetiology, likely involving genetic and environmental risk factors (RF). The aim of this paper is to develop the paediatric environmental clinical history (PECH) of two patients with gastroschisis. Review of the medical literature using Pubmed and the Developmental and Reproductive Toxicology Database. Search teratogenic substances using the Hazardous Substances Data Bank. Keywords used were: "Gastroschisis" and "Gastroschisis and Risk Factor". Among the RFs known and present in both cases were: short cohabitation, unintended pregnancies of relatively young mothers, recent change of paternity, excessive alcohol intake, important nutritional deficiencies, and active and passive smoking. Additionally, one of the cases was exposed to cocaine, cannabis smoke and ionizing radiation from an orthopantography during pregnancy. 1. The PECH should be obtained in all patients with gastroschisis. 2. A thorough PECH requires a proper review of the related RFs and basic training to characterise and quantify environmental exposures. 3. Following these steps, useful recommendations to improve patient care and family advice in future pregnancies are provided.
References
Apr 1, 1992·Teratology·M M WerlerS Shapiro
Jul 1, 1994·Teratology·C P TorfsC J Curry
Mar 1, 1993·Teratology·J E HaddowM S Holman
Aug 1, 1996·Teratology·C P TorfsC J Curry
Jan 23, 1999·Teratology·C P TorfsR J Brand
Oct 27, 1999·Epidemiology·P K LamR J Brand
Dec 26, 2002·American Journal of Obstetrics and Gynecology·Eran KozerGideon Koren
Jul 16, 2003·Epidemiology·Martha M WerlerAllen A Mitchell
Feb 11, 2004·American Journal of Epidemiology·Method R KazauraTor Bjerkedal
Sep 16, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jennita Reefhuis, Margaret A Honein
Mar 4, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Laura J WilliamsAdolfo Correa
Feb 4, 2006·BMJ : British Medical Journal·Mark D Kilby
Feb 25, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Phung K Lam, Claudine P Torfs
Oct 20, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Mark A CanfieldRussell S Kirby
Nov 23, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Natalie P ArcherRam Shanmugam
Mar 16, 2007·American Journal of Medical Genetics. Part a·Pierpaolo MastroiacovoLyubov Yevtushok
Mar 16, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Monica RittlerJorge S Lopez-Camelo
Aug 8, 2007·Archives of Pediatrics & Adolescent Medicine·D Kim WallerUNKNOWN National Birth Defects Prevention Study
Sep 4, 2007·International Journal of Hygiene and Environmental Health·Juan Antonio Ortega GarcíaJuan Alonso López Andreu
Dec 8, 2007·American Journal of Epidemiology·Elizabeth S DraperJennifer J Kurinczuk