Integrating the inputs that shape pancreatic islet hormone release

Nature Metabolism
Glyn M Noguchi, Mark O Huising

Abstract

The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and their support cells, which together tightly control blood glucose homeostasis. Changes in glucose concentration are commonly regarded as the chief signal controlling insulin-secreting beta cells, glucagon-secreting alpha cells and somatostatin-secreting delta cells. However, each of these cell types is highly responsive to a multitude of endocrine, paracrine, nutritional and neural inputs, which collectively shape the final endocrine output of the islet. Here, we review the principal inputs for each islet-cell type and the physiological circumstances in which these signals arise, through the prism of the insights generated by the transcriptomes of each of the major endocrine-cell types. A comprehensive integration of the factors that influence blood glucose homeostasis is essential to successfully improve therapeutic strategies for better diabetes management.

References

Feb 1, 1976·The Journal of Clinical Endocrinology and Metabolism·J MarcoM L Villanueva
Dec 1, 1976·Gut·T E AdrianA J Barnes
Jul 7, 1992·Biochemical Pharmacology·M Michalik, M Erecińska
Oct 17, 1989·Biochimica Et Biophysica Acta·C GuettetB Lecuyer
Jul 6, 1988·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·E N BakerC D Reynolds
Aug 1, 1986·The Journal of Clinical Endocrinology and Metabolism·M A NauckW Creutzfeldt
Sep 1, 1972·The Journal of Clinical Investigation·D M RochaR H Unger
May 1, 1974·The Journal of Clinical Investigation·J E GerichC Noacco
Mar 1, 1984·The Journal of Clinical Investigation·G BodenO E Owen
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P PetruszA V Schally
Jan 1, 1980·Scandinavian Journal of Gastroenterology·K B LauritsenS Lindkaer Jensen
Nov 1, 1995·The Journal of Clinical Investigation·A De VosF Schuit
Jan 28, 1994·Biochemical and Biophysical Research Communications·Y C PatelC B Srikant
Feb 9, 2002·European Journal of Endocrinology·E M EgidoJ Marco
Nov 26, 2002·Journal of Cellular Physiology·E P HaberA R Carpinelli
Dec 12, 2002·Diabetes·Patrick E MacDonaldMichael B Wheeler
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·R W GellingM J Charron
Feb 15, 2003·Endocrinology·Martina Kvist ReimerBo Ahrén
Mar 18, 2003·Nature Cell Biology·Hisamitsu IshiharaClaes B Wollheim
May 27, 2003·Diabetes Care·Philip E CryerHarry Shamoon
Aug 14, 2003·The Journal of Clinical Endocrinology and Metabolism·R L BatterhamS R Bloom
Oct 1, 1963·The American Journal of Physiology·G M GRODSKYD F SMITH
Oct 1, 1964·The Journal of Clinical Endocrinology and Metabolism·H ELRICKY ARAI
Aug 28, 1965·Lancet·E SAMOLSV MARKS
Sep 30, 2004·American Journal of Physiology. Endocrinology and Metabolism·Chen WangDaniel Pipeleers
Dec 21, 2004·Biochemical and Biophysical Research Communications·Takatoshi SogaKiyoshi Furuichi
Jun 1, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Marcela BrissovaAlvin C Powers
Jul 23, 2005·Journal of Leukocyte Biology·S B GeutskensP J M Leenen

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Citations

Sep 8, 2020·Diabetologia·Mark O Huising
May 20, 2020·Frontiers in Oncology·Polina Schwartsburd
Oct 23, 2020·Islets·Gerardo J Félix-MartínezJ Rafael Godínez-Fernández
Oct 27, 2020·American Journal of Physiology. Endocrinology and Metabolism·Jean-Claude Henquin
Jan 27, 2021·Biology·Rui GaoQuan Zhang
Sep 29, 2020·Pharmacology & Therapeutics·Patricia Seoane-CollazoMiguel López
May 7, 2021·Cellular and Molecular Gastroenterology and Hepatology·Noga KorenfeldIdo Goldstein
May 6, 2021·Diabetes·Mollie S H FriedlanderRomina J Bevacqua
Aug 12, 2021·Nature Reviews. Drug Discovery·Johanna SiehlerHeiko Lickert
Apr 13, 2021·Endocrine Reviews·John T WalkerAlvin C Powers

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Methods Mentioned

BETA
RNA-seq

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