Integrating Thyroid Hormone Signaling in Hypothalamic Control of Metabolism: Crosstalk Between Nuclear Receptors

International Journal of Molecular Sciences
Soumaya Kouidhi, Marie-Stéphanie Clerget-Froidevaux

Abstract

The obesity epidemic is well recognized as a significant global health issue. A better understanding of the energy homeostasis mechanisms could help to identify promising anti-obesity therapeutic strategies. It is well established that the hypothalamus plays a pivotal role governing energy balance. The hypothalamus consists of tightly interconnected and specialized neurons that permit the sensing and integration of several peripheral inputs, including metabolic and hormonal signals for an appropriate physiological response. Current evidence shows that thyroid hormones (THs) constitute one of the key endocrine factors governing the regulation and the integration of metabolic homeostasis at the hypothalamic level. THs modulate numerous genes involved in the central control of metabolism, as TRH (Thyrotropin-Releasing Hormone) and MC4R (Melanocortin 4 Receptor). THs act through their interaction with thyroid hormone receptors (TRs). Interestingly, TH signaling, especially regarding metabolic regulations, involves TRs crosstalk with other metabolically linked nuclear receptors (NRs) including PPAR (Peroxisome proliferator-activated receptor) and LXR (Liver X receptor). In this review, we will summarize current knowledge on the impo...Continue Reading

References

Mar 1, 1992·Genes & Development·D J MangelsdorfR M Evans
Aug 1, 1995·Genes & Development·B P Leblanc, H G Stunnenberg
Dec 5, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H GuissoumaB A Demeneix
Jul 19, 2001·The Journal of Biological Chemistry·E D Rosen, B M Spiegelman
Jun 29, 2002·Molecular Endocrinology·Hajer GuissoumaBarbara A Demeneix
Jul 10, 2003·Annals of the New York Academy of Sciences·Andrew A Butler, Roger D Cone
Feb 11, 2004·Biochemistry·Jarkko HuuskonenChristopher J Fielding
Aug 12, 2005·The New England Journal of Medicine·Andrew I Shulman, David J Mangelsdorf
Sep 15, 2005·Nature Neuroscience·Eva GroppJens C Brüning
Nov 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Osamu ArakiSheue-Yann Cheng
Dec 13, 2005·The Journal of Biological Chemistry·Amisra A NikrodhanondFredric E Wondisford
Jan 26, 2006·Peptides·Andrew A Butler
Jan 31, 2006·Molecular and Cellular Endocrinology·Paul M YenXianmin Xia
Aug 1, 2006·Progress in Brain Research·Eric FliersDick F Swaab
Feb 22, 2007·The Journal of Biological Chemistry·Lara F R VelascoFrancisco A R Neves
Mar 17, 2007·Critical Reviews in Toxicology·R Thomas ZoellerRochelle W Tyl
May 18, 2007·Annual Review of Neuroscience·Qian Gao, Tamas L Horvath
Aug 19, 2007·The Journal of Clinical Investigation·Manu V ChakravarthyClay F Semenkovich
Sep 4, 2007·Nutrition & Metabolism·George Wm Millington
Dec 2, 2008·Nature·Vikas ChandraFraydoon Rastinejad
Apr 2, 2009·Nature Reviews. Drug Discovery·John D Baxter, Paul Webb

❮ Previous
Next ❯

Citations

Nov 13, 2019·Environmental Science and Pollution Research International·Carolyn KlockePamela J Lein
Mar 19, 2020·International Journal of Molecular Sciences·Grazia RutiglianoGrazia Chiellini
Mar 20, 2019·Nature Reviews. Endocrinology·Cintia E CitterioPeter Arvan
Oct 14, 2020·Aging Cell·Benoit R GauthierAlejandro Martin-Montalvo
Nov 27, 2020·Frontiers in Endocrinology·Cole K Deal, Helene Volkoff
Aug 25, 2021·Tropical Animal Health and Production·A J Landaeta-HernándezT A Olson

❮ Previous
Next ❯

Methods Mentioned

BETA
ChIP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Trends in Endocrinology and Metabolism : TEM
Yan-Yun Liu, Gregory A Brent
Thyroid : Official Journal of the American Thyroid Association
Anthony N Hollenberg
Physiological Reviews
Rashmi MullurGregory A Brent
© 2022 Meta ULC. All rights reserved