Integrating time from experience in the lateral entorhinal cortex

Nature
Albert TsaoEdvard I Moser

Abstract

The encoding of time and its binding to events are crucial for episodic memory, but how these processes are carried out in hippocampal-entorhinal circuits is unclear. Here we show in freely foraging rats that temporal information is robustly encoded across time scales from seconds to hours within the overall population state of the lateral entorhinal cortex. Similarly pronounced encoding of time was not present in the medial entorhinal cortex or in hippocampal areas CA3-CA1. When animals' experiences were constrained by behavioural tasks to become similar across repeated trials, the encoding of temporal flow across trials was reduced, whereas the encoding of time relative to the start of trials was improved. The findings suggest that populations of lateral entorhinal cortex neurons represent time inherently through the encoding of experience. This representation of episodic time may be integrated with spatial inputs from the medial entorhinal cortex in the hippocampus, allowing the hippocampus to store a unified representation of what, where and when.

References

Aug 14, 1998·The Journal of Comparative Neurology·C L Dolorfo, D G Amaral
Sep 29, 1998·Nature·N S Clayton, A Dickinson
Apr 27, 2002·Nature Neuroscience·Norbert J FortinHoward B Eichenbaum
Jun 26, 2004·Annual Review of Neuroscience·Michael D Mauk, Dean V Buonomano
Aug 15, 2006·Hippocampus·Janina FerbinteanuMatthew L Shapiro
Jun 6, 2007·Trends in Cognitive Sciences·Demis Hassabis, Eleanor A Maguire
Sep 6, 2008·Science·Eva PastalkovaGyörgy Buzsáki
Jan 16, 2009·Nature Reviews. Neuroscience·Dean V Buonomano, Wolfgang Maass
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hanne LehnAsta K Håberg
Oct 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Dezhe Z JinAnn M Graybiel
Jun 19, 2010·Science·Rosamund F LangstonMay-Britt Moser
Aug 6, 2011·Science·Yuji Naya, Wendy A Suzuki
Aug 27, 2011·Neuron·Christopher J MacDonaldHoward Eichenbaum
Nov 9, 2011·Frontiers in Behavioral Neuroscience·Sachin S Deshmukh, James J Knierim
Mar 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·James M HymanJeremy K Seamans
Nov 8, 2012·Proceedings of the National Academy of Sciences of the United States of America·Emily A MankinJill K Leutgeb
Feb 12, 2013·Nature Neuroscience·Yaniv ZivMark J Schnitzer
Feb 26, 2013·Current Biology : CB·Albert TsaoEdvard I Moser
May 21, 2013·Nature·Mattia RigottiStefano Fusi
Jun 4, 2013·Annual Review of Neuroscience·Hugo MerchantWarren H Meck
Jul 16, 2013·Nature Neuroscience·Li LuEdvard I Moser
Mar 13, 2014·Neuron·Liang-Tien HsiehCharan Ranganath
Mar 29, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marc W HowardHoward Eichenbaum
Oct 2, 2014·Nature Reviews. Neuroscience·Howard Eichenbaum
Apr 8, 2015·Proceedings of the National Academy of Sciences of the United States of America·Mihail BotaLarry W Swanson
Jul 16, 2015·Nature·Emilio KropffEdvard I Moser
Oct 16, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gerald T FinnertyDean V Buonomano
Nov 6, 2015·Neuron·Benjamin J KrausHoward Eichenbaum
Mar 30, 2016·Annual Review of Neuroscience·David C RowlandEdvard I Moser
Apr 1, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher S KeeneHoward Eichenbaum
Nov 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Adam J O DedeLarry R Squire
Sep 1, 2017·Neuron·Howard Eichenbaum
Oct 28, 2017·Science·György Buzsáki, Rodolfo Llinás
Apr 5, 2018·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah FolkertsMarc W Howard

❮ Previous
Next ❯

Citations

Apr 5, 2019·Learning & Behavior·Catalin V Buhusi
Jul 25, 2019·Hippocampus·Jørgen Sugar, May-Britt Moser
Jul 12, 2019·The European Journal of Neuroscience·Asgeir Kobro-Flatmoen, Menno P Witter
Dec 31, 2019·Hippocampus·Richard GörlerSen Cheng
Dec 11, 2019·Journal of Cognitive Neuroscience·Peter KokNicholas B Turk-Browne
Feb 21, 2019·Nature Communications·Pierre-Yves JacobFrancesca Sargolini
Apr 15, 2020·Scientific Reports·Karolina M LempertJoseph W Kable
Apr 7, 2020·Nature Neuroscience·Chen SunSusumu Tonegawa
May 21, 2020·Neural Computation·Yue Liu, Marc W Howard
Jun 13, 2020·Journal of Cognitive Neuroscience·Jacob L S BellmundChristian F Doeller
Jun 26, 2020·Brain and Behavior·Hiram Luna-MunguiaLuis Concha
Jan 22, 2020·Annual Review of Neuroscience·John B IssaDaniel A Dombeck
Mar 7, 2020·The Journal of Comparative Neurology·Olivia PiguetPierre Lavenex
May 28, 2020·Journal of Cognitive Neuroscience·Baptiste GauthierVirginie van Wassenhove
Aug 12, 2020·The Journal of Comparative Neurology·George Andrew Reid, Sultan Darvesh
Jun 26, 2020·Annual Review of Vision Science·Aaron D Garcia, Elizabeth A Buffalo
Jan 16, 2019·Nature Communications·Mostafa M El-KallinyKareem A Zaghloul
Aug 7, 2019·ELife·Jacob Ls BellmundChristian F Doeller
Oct 3, 2018·Nature Reviews. Neuroscience·Katherine Whalley
Jun 30, 2019·Journal of Cognitive Neuroscience·Holger DannenbergMichael E Hasselmo
Jan 16, 2019·Nature Neuroscience·Maria E MontchalMichael A Yassa
Nov 5, 2019·Frontiers in Systems Neuroscience·Shinya OharaMenno P Witter
Jan 4, 2020·The Behavioral and Brain Sciences·Vishnu SreekumarSimon J Dennis
Aug 5, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ian M BrightMarc W Howard
Nov 10, 2018·Science·Jacob L S BellmundChristian F Doeller
May 28, 2019·Computational Brain & Behavior·Marc W HowardZoran Tiganj
Jan 16, 2019·Nature Neuroscience·Matthew L Shapiro
Mar 14, 2019·Proceedings of the National Academy of Sciences of the United States of America·Sathesan ThavabalasingamAndy C H Lee
Feb 12, 2020·Nature Reviews. Neuroscience·Thomas Hainmueller, Marlene Bartos
Oct 21, 2020·Neural Computation·Wouter KruijneChristian N L Olivers
Jan 13, 2021·Proceedings of the National Academy of Sciences of the United States of America·Christopher J MacDonald, Susumu Tonegawa

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA

Software Mentioned

LIBLINEAR
Neuralynx
MATLAB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.