Integrating value of research into NCI Clinical Trials Cooperative Group research review and prioritization: A pilot study

Cancer Medicine
Josh J CarlsonScott D Ramsey

Abstract

The Institute of Medicine has called for approaches to help maximize the return on investments (ROI) in cancer clinical trials. Value of Research (VOR) is a health economics technique that estimates ROI and can inform research prioritization. Our objective was to evaluate the impact of using VOR analyses on the clinical trial proposal review process within the SWOG cancer clinical trials consortium. We used a previously developed minimal modeling approach to calculate VOR estimates for 9 phase II/III SWOG proposals between February 2015 and December 2016. Estimates were presented to executive committee (EC) members (N = 12) who determine which studies are sent to the National Cancer Institute for funding consideration. EC members scored proposals from 1 (best) to 5 based on scientific merit and potential impact before and after receiving VOR estimates. EC members were surveyed to assess research priorities, proposal evaluation process satisfaction, and the VOR process. Value of Research estimates ranged from -$2.1B to $16.46B per proposal. Following review of VOR results, the EC changed their score for eight of nine proposals. Proposal rankings were different in pre- vs postscores (P value: 0.03). Respondents had mixed views of...Continue Reading

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Citations

Aug 11, 2021·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Sabine E GrimmManuela A Joore

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