Integration of antimicrobial peptides and gold nanorods for bimodal antibacterial applications

Biomaterials Science
Jin ChenLanjuan Li

Abstract

The misuse and abuse of antibiotics have given rise to a severe problem of the drug resistance of bacteria. Solving this problem has been a vitally important task in the modern medical arena. In this work, an antimicrobial peptide (AMP), BF2b, and gold nanorods (AuNRs) were used to develop a specific drug delivery system for killing methicillin-resistant Staphylococcus aureus (MRSA). On the one hand, BF2b has unique anti-bacterial performance and has a lower tendency than traditional antibiotics to engender the drug resistance of bacteria. On the other hand, AuNRs have diverse distinct properties, such as photo-thermal conversion, which can be employed for photo-thermal sterilization. We aimed to integrate the anti-bacterial activity of BF2b and the photo-thermal sterilization of AuNRs to kill drug-resistant bacteria. Fourier-transform infrared spectroscopy, microBCA and zeta potential measurements were utilized to characterize the product, AuNR@PEG/BF2b. Transmittance electron microscopy, UV-vis spectroscopy and photothermal conversion measurement were conducted to verify the stability and photothermal conversion capacity of AuNR@PEG/BF2b. Cell viability and hemolysis assay were carried out to test the biocompatibility of AuNR...Continue Reading

References

Nov 24, 2004·Infection and Immunity·Miguel A CamposJosé A Bengoechea
Feb 11, 2005·Nature Reviews. Microbiology·Kim A Brogden
Apr 6, 2012·Journal of Medicinal Chemistry·Youhong NiuJianfeng Cai
Apr 20, 2012·Mini Reviews in Medicinal Chemistry·A Brandelli
Jun 29, 2012·Advanced Materials·Leonid VigdermanEugene R Zubarev
Nov 7, 2012·Chemical Society Reviews·Huanjun ChenJianfang Wang
Jan 31, 2013·Bioconjugate Chemistry·Fei RenXiaohua Huang
May 30, 2013·Antimicrobial Agents and Chemotherapy·Hung-Lun ChuJya-Wei Cheng
May 9, 2014·ACS Applied Materials & Interfaces·Tengfei TianZhuang Liu
Nov 6, 2014·Expert Review of Anti-infective Therapy·Su-Jin KangBong-Jin Lee
Aug 22, 2015·Chemical Reviews·Xuan YangYounan Xia
Jan 15, 2016·Current Biology : CB·Ling-Juan Zhang, Richard L Gallo
May 27, 2017·Chemical Biology & Drug Design·Urszula PiotrowskaEwa Oledzka
Jun 4, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Patrícia SeverinoEliana B Souto
Aug 8, 2017·Advanced Materials·Guo-Bin QiHao Wang
Sep 12, 2017·Bioconjugate Chemistry·Urawadee Rajchakit, Vijayalekshmi Sarojini
Nov 11, 2017·Nature Communications·Yujia LiangQian Liu
Jan 13, 2018·Science Translational Medicine·Anna de BreijPeter H Nibbering
Feb 1, 2018·Biomaterials Science·Mark GontsarikStefan Salentinig
Feb 3, 2018·Applied Microbiology and Biotechnology·Arnau BassegodaTzanko Tzanov
Feb 21, 2018·Advanced Materials·Guo-Bin QiHao Wang
Mar 20, 2018·Journal of Nanobiotechnology·Menglong LiuJun Deng
Apr 13, 2018·ACS Applied Materials & Interfaces·Tianjiao DaiYiyun Cheng
Jun 6, 2018·Frontiers in Microbiology·Lubhandwa S BiswaroOctavio L Franco

❮ Previous
Next ❯

Citations

Jan 6, 2021·Advanced Drug Delivery Reviews·Yunjiang JiangJianjun Cheng
Jun 24, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bicong ZhouChangmin Yu

❮ Previous
Next ❯

Methods Mentioned

BETA
protein assay
infrared spectroscopy
dynamic light scattering
surface plasmon resonance

Software Mentioned

Origin

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.