Integration of cell-cell adhesion and contractile actomyosin activity during morphogenesis

Current Topics in Developmental Biology
Katja Röper

Abstract

During embryonic development, cells become organized into complex tissues. Cells need to adhere and communicate with their immediate and remote neighbors to allow morphogenesis to take place in a coordinated way. Cell-cell adhesion, mediated by transmembrane adhesion receptors such as Cadherins and their intracellular interaction partners, is intimately linked to cell contractility that drives cell shape changes. Research in recent years has revealed that the contractile machinery responsible for cell shape changes, actomyosin, can in fact be organized into a number of different functional assemblies such as cortical-junctional actomyosin, apical-medial actomyosin, supracellular actomyosin cables as well as basal actomyosin networks. During coordinated shape changes of a tissue, these assemblies have to be functionally and mechanically linked between cells through cell-cell junctions. Although many actin-binding proteins associated with adherens junctions have been identified, which specific factors are required for the linkage of particular actomyosin assemblies to junctions is not well understood. This review will summarize our current knowledge, based mainly on the in vivo study of morphogenesis in the fruit fly Drosophila m...Continue Reading

Citations

May 7, 2016·Cellular and Molecular Life Sciences : CMLS·Peter Coopman, Alexandre Djiane
Nov 5, 2016·The Journal of Cell Biology·Marie Anne O'Donnell
Sep 5, 2015·F1000Research·Olga Klezovitch, Valeri Vasioukhin
Mar 7, 2018·The Journal of Cell Biology·Nadia Efimova, Tatyana M Svitkina
Jan 13, 2018·The Journal of Cell Biology·Giorgos TsoumpekosElisabeth Knust
Sep 15, 2017·The Journal of Cell Biology·Yuliya ZilbermanJeremy Nance
Jul 19, 2017·Cold Spring Harbor Perspectives in Biology·Christine Chiasson-MacKenzie, Andrea I McClatchey
Oct 29, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nicole Gorfinkiel
Jul 18, 2018·ELife·Yara E Sanchez-CorralesKatja Röper
Aug 17, 2018·Genesis : the Journal of Genetics and Development·Felipe Berti ValerRicardo Guelerman Pinheiro Ramos
May 10, 2019·Cell Cycle·Tara M Finegan, Dan T Bergstralh
Aug 25, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tara M Finegan, Dan T Bergstralh
Dec 17, 2017·Journal of Cell Science·Julie MilaniniFrédéric Luton
Oct 11, 2017·Annual Review of Cell and Developmental Biology·Daniel P KiehartGlenn S Edwards
Aug 11, 2019·Development·Ramya BalajiAnne-Kathrin Classen
Dec 5, 2020·Current Biology : CB·Mariam HachimiFernando Martin-Belmonte
Dec 19, 2017·Experimental Cell Research·Caitlin M LoganA Sue Menko
Aug 20, 2020·Chemical Reviews·Hongjian HeBing Xu
May 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Eirini ManiouGabriel L Galea

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