Integration of clinical data, pathology, and cDNA microarrays in influenza virus-infected pigtailed macaques (Macaca nemestrina)

Journal of Virology
Carole R BaskinMichael G Katze

Abstract

For most severe viral pandemics such as influenza and AIDS, the exact contribution of individual viral genes to pathogenicity is still largely unknown. A necessary step toward that understanding is a systematic comparison of different influenza virus strains at the level of transcriptional regulation in the host as a whole and interpretation of these complex genetic changes in the context of multifactorial clinical outcomes and pathology. We conducted a study by infecting pigtailed macaques (Macaca nemestrina) with a genetically reconstructed strain of human influenza H1N1 A/Texas/36/91 virus and hypothesized not only that these animals would respond to the virus similarly to humans, but that gene expression patterns in the lungs and tracheobronchial lymph nodes would fit into a coherent and complete picture of the host-virus interactions during infection. The disease observed in infected macaques simulated uncomplicated influenza in humans. Clinical signs and an antibody response appeared with induction of interferon and B-cell activation pathways, respectively. Transcriptional activation of inflammatory cells and apoptotic pathways coincided with gross and histopathological signs of inflammation, with tissue damage and concur...Continue Reading

References

Jan 1, 1977·Cell·P Palese
Jul 1, 1988·Journal of Clinical Microbiology·L F CassidyJ S Abramson
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·F Arenzana-SeisdedosJ L Virelizier
Jan 1, 1986·Current Topics in Microbiology and Immunology·G L Ada, P D Jones
Jun 19, 1987·The American Journal of Medicine·T R Cate
May 1, 1980·Antimicrobial Agents and Chemotherapy·F G HaydenR G Douglas
Apr 21, 1994·Journal of Theoretical Biology·G A Bocharov, A A Romanyukha
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·S BahramT Spies
Jan 1, 1996·Free Radical Biology & Medicine·K B Schwarz
Mar 21, 1997·Science·J K TaubenbergerT G Fanning
Apr 16, 1998·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·A MorettaR Millo
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·A H ReidJ K Taubenberger
Oct 8, 1999·Emerging Infectious Diseases·M I MeltzerK Fukuda
Oct 9, 1999·Journal of Virology·E FodorA García-Sastre
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J E DurbinD E Levy
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·A H ReidJ K Taubenberger
Jul 25, 2000·The Journal of Infection·J C De JongA D Osterhaus
Aug 31, 2000·Virology·J K TaubenbergerT G Fanning
Feb 15, 2001·The Journal of Infectious Diseases·L V GubarevaF G Hayden
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·C F BaslerJ K Taubenberger
Mar 23, 2001·Reviews in Medical Virology·T Akaike
Jun 20, 2001·Journal of Virology·G F RimmelzwaanA D Osterhaus
Jun 29, 2001·Trends in Immunology·H A Stephens
Apr 5, 2002·Journal of Virology·Lois A ZitzowJacqueline M Katz
Jul 3, 2002·The Journal of Clinical Investigation·Peter Palese, Adolfo García-Sastre
Aug 6, 2002·Current Opinion in Microbiology·Jonathan Yewdell, Adolfo García-Sastre
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Terrence M TumpeyChristopher F Basler
Oct 12, 2002·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Eun A KimJoungho Han

❮ Previous
Next ❯

Citations

Feb 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Carole R BaskinMichael G Katze
Jun 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David S Fedson
Dec 8, 2006·The Journal of Infectious Diseases·Dan HuangZheng W Chen
Mar 8, 2008·ILAR Journal·Murray B Gardner, Paul A Luciw
Oct 19, 2007·Journal of Virology·Yueh-Ming LooMichael Gale
Jan 18, 2008·Journal of Virology·Jan DittmannGeorg Kochs
Nov 9, 2012·Journal of Virology·Anh T TranKevin M Coombs
Apr 20, 2007·Journal of Virology·Georg KochsLuis Martínez-Sobrido
Nov 28, 2007·Annual Review of Pathology·Jeffery K Taubenberger, David M Morens
Nov 22, 2007·American Journal of Respiratory and Critical Care Medicine·Christina C LewisDavid J Erle
Apr 15, 2014·BMC Infectious Diseases·Jin LvQi-Sheng Jiang
Sep 18, 2012·Critical Reviews in Microbiology·Derrick LouzRob C Hoeben
Jul 14, 2011·Expert Opinion on Drug Metabolism & Toxicology·Maryna C Eichelberger, Martin D Green
Feb 1, 2011·Microbes and Infection·Christopher D O'Donnell, Kanta Subbarao
May 9, 2006·Current Opinion in Microbiology·Minghsun LiuDavid A Relman
Jan 30, 2009·Antiviral Research·Dale L Barnard
Jan 8, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jeppe S SpickerHenrik Toft
Aug 5, 2010·Veterinary Pathology·T KuikenD E Swayne
Mar 21, 2018·Nature Reviews. Immunology·Jacob D EstesJason M Brenchley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.