Integration of data derived from biological variation into the quality management system

Clinica Chimica Acta; International Journal of Clinical Chemistry
Carmen RicósMargarita Simón

Abstract

[corrected] Data on within- and between-subject biological variation are available for around 250 analytes commonly used in medical laboratories. Integration of this data into the quality system occurs at all three levels of laboratory activity: (a) Preanalytic process: biological variation provides the basis for selecting the most appropriate specimen for analysis, for defining sample stability and for deciding suitable timing between samplings; (b) analytic process: biological variation-derived goals are fundamental for designing internal quality control procedures, and for evaluating laboratory performance; and (c) postanalytic process: delta checks based on within-subject biological variation values are used for validating results and for interpreting serial results from a patient. The biological variation is a pillar for managing quality in laboratory medicine.

References

Jun 22, 2001·Pflügers Archiv : European journal of physiology·O LevillainW G Guder
Jun 26, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·O AspevallT Kouri

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Citations

Mar 8, 2008·Journal of Clinical Pathology·Fierdoz OmarTahir S Pillay

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