Integration of developmental and environmental signals into cell proliferation and differentiation through RETINOBLASTOMA-RELATED 1

Current Opinion in Plant Biology
Hirofumi Harashima, Keiko Sugimoto

Abstract

Plants continuously form new organs during post-embryonic development, thus progression of the proliferative cell cycle and subsequent transition into differentiation must be tightly controlled by developmental and environmental cues. Recent studies have begun to uncover how cell proliferation and cell differentiation are coordinated at the molecular level through tight transcriptional regulation of cell cycle and/or developmental regulators. Accumulating evidence suggests that RETINOBLASTOMA-RELATED 1 (RBR1), the Arabidopsis homolog of the human tumor suppressor Retinoblastoma (Rb), functions as a molecular hub linking cell proliferation, differentiation, and environmental response. In this review we will discuss recent findings on cell cycle regulation, highlighting the emerging roles of RBR1 as a key integrator of internal differentiation cues and external stimuli into the cell cycle machinery.

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Citations

Jul 13, 2016·Trends in Plant Science·Crisanto Gutierrez
Nov 7, 2016·Current Opinion in Plant Biology·Zoltán MagyarMasaki Ito
Mar 29, 2019·Journal of Experimental Botany·Zaki AhmadCsaba Papdi
Sep 1, 2020·The EMBO Journal·Bénédicte Desvoyes, Crisanto Gutierrez
Sep 30, 2020·Nature Plants·Bénédicte DesvoyesCrisanto Gutierrez
Dec 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Lisa WillisHenrik Jönsson
Apr 30, 2017·Science·Xin'Ai ZhaoArp Schnittger
May 2, 2017·Antioxidants & Redox Signaling·Ambra de SimoneChristine H Foyer
Sep 28, 2018·Current Opinion in Plant Biology·Michelle R FacetteJaimie M Van Norman
Mar 2, 2021·Frontiers in Plant Science·Luiz M CabralAdriana S Hemerly
Feb 7, 2021·The Plant Journal : for Cell and Molecular Biology·Jiewei ShiGuogui Ning
Jun 12, 2021·Science·Marco D'ArioRobert Sablowski
Sep 18, 2021·Annual Review of Genetics·Franziska Böwer, Arp Schnittger
Dec 4, 2021·The Plant Journal : for Cell and Molecular Biology·María Sol GómezPaula Casati

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