Integration of Drosophila and Human Genetics to Understand Notch Signaling Related Diseases

Advances in Experimental Medicine and Biology
Jose L Salazar, Shinya Yamamoto

Abstract

Notch signaling research dates back to more than one hundred years, beginning with the identification of the Notch mutant in the fruit fly Drosophila melanogaster. Since then, research on Notch and related genes in flies has laid the foundation of what we now know as the Notch signaling pathway. In the 1990s, basic biological and biochemical studies of Notch signaling components in mammalian systems, as well as identification of rare mutations in Notch signaling pathway genes in human patients with rare Mendelian diseases or cancer, increased the significance of this pathway in human biology and medicine. In the 21st century, Drosophila and other genetic model organisms continue to play a leading role in understanding basic Notch biology. Furthermore, these model organisms can be used in a translational manner to study underlying mechanisms of Notch-related human diseases and to investigate the function of novel disease associated genes and variants. In this chapter, we first briefly review the major contributions of Drosophila to Notch signaling research, discussing the similarities and differences between the fly and human pathways. Next, we introduce several biological contexts in Drosophila in which Notch signaling has been...Continue Reading

Citations

Jul 8, 2020·Biomolecules·Jose L SalazarShinya Yamamoto
Jan 22, 2021·Lab Animal·Ellen P Neff
Mar 2, 2021·Pathology, Research and Practice·Zuo-Long WuHai-Hong Zhang
Mar 2, 2021·The FEBS Journal·Debdeep DuttaAshim Mukherjee
Apr 4, 2021·International Journal of Molecular Sciences·J Michael HarnishShinya Yamamoto
May 12, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Fred E Bertrand

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