Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure.

Environment International
Simon Kebede MeridOlena Gruzieva

Abstract

Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this meta-analysis of transcriptome-wide association studies of 656 children and adolescents from three European cohorts participating in the MeDALL Consortium, we found two differentially expressed transcript clusters (FDR p < 0.05) associated with exposure to particulate matter < 2.5 µm in diameter (PM2.5) at birth, one of them mapping to the MIR1296 gene. Further, by integrating gene expression with DNA methylation using Functional Epigenetic Modules algorithms, we identified 9 and 6 modules in relation to PM2.5 exposure at birth and at current address, respectively (including NR1I2, MAPK6, TAF8 and SCARA3). In conclusion, PM2.5 exposure at birth was linked to differential gene expression in children and adolescents. Importantly, we identified several significant interactome hotspots of gene modules of relevance for complex diseases in relation to PM2.5 exposure.

References

Feb 6, 2004·Development·Huajing WanJeffrey A Whitsett
Oct 6, 2004·Genome Biology·Robert C GentlemanJianhua Zhang
Jan 26, 2005·The Journal of Biological Chemistry·Huajing WanJeffrey A Whitsett
Jun 17, 2005·Nature·Catherine S LeeKlaus H Kaestner
Apr 25, 2006·Biostatistics·W Evan JohnsonAriel Rabinovic
Aug 16, 2006·Cellular and Molecular Life Sciences : CMLS·J R Friedman, K H Kaestner
May 29, 2010·Inhalation Toxicology·Yuh-Chin T HuangRobert B Devlin
Jul 10, 2010·Bioinformatics·Cristen J WillerGonçalo R Abecasis
Feb 3, 2011·Occupational and Environmental Medicine·Marloes EeftensGerard Hoek
Apr 8, 2011·International Journal of Epidemiology·Mònica GuxensUNKNOWN INMA Project
Oct 8, 2013·The Journal of Allergy and Clinical Immunology·Olena GruzievaGöran Pershagen
Jan 17, 2014·The Lancet. Respiratory Medicine·Marie PedersenRémy Slama
Jan 28, 2014·Nature Methods·Bo WangAnna Goldenberg
Oct 18, 2014·The European Respiratory Journal·Anna MölterRaymond Agius
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
Feb 3, 2015·Journal of Cardiovascular Medicine·Huseyin Altug CakmakVural Ali Vural
Feb 27, 2015·Annals of the New York Academy of Sciences·Frank J Kelly, Julia C Fussell
Mar 31, 2015·Nature Methods·Aaron M NewmanAsh A Alizadeh
May 7, 2016·Nucleic Acids Research·Christoph OgrisErik L L Sonnhammer
May 26, 2016·Particle and Fibre Toxicology·Gajalakshmi RamanathanJesus A Araujo
Jul 23, 2016·Environmental Health Perspectives·Olena GruzievaErik Melén
Aug 2, 2016·American Journal of Respiratory and Critical Care Medicine·Erica S SchultzErik Melén
Sep 25, 2016·Nucleic Acids Research·Christoph OgrisErik L L Sonnhammer
Oct 28, 2016·Balkan Journal of Medical Genetics : BJMG·S Karachanak-YankovaI Dimova
Nov 5, 2016·Environmental Health : a Global Access Science Source·Jen-Hwa ChuFrancine Laden
Dec 3, 2016·American Journal of Respiratory and Critical Care Medicine·Anna GrefErik Melén
Feb 6, 2017·Epidemiology·Nahid MostafaviRoel Vermeulen
Aug 27, 2017·Environment International·Michelle PlusquinMarc Chadeau-Hyam

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Citations

Feb 24, 2021·Current Opinion in Allergy and Clinical Immunology·Olena GruzievaErik Melén
Sep 10, 2021·Environmental Science and Pollution Research International·Suranjana MukherjeeKoel Chaudhury

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