Integration of intercellular signaling through the Hippo pathway.

Seminars in Cell & Developmental Biology
Kenneth D Irvine

Abstract

Metazoan cells are exposed to a multitude of signals, which they integrate to determine appropriate developmental or physiological responses. Although the Hippo pathway was only discovered recently, and our knowledge of Hippo signal transduction is far from complete, a wealth of interconnections amongst Hippo and other signaling pathways have already been identified. Hippo signaling is particularly important for growth control, and I describe how integration of Hippo and other pathways contributes to regulation of organ growth. Molecular links between Hippo signaling and other signal transduction pathways are summarized. Different types of mechanisms for signal integration are described, and examples of how the complex interconnections between pathways are used to guide developmental and physiological growth responses are discussed. Features of Hippo signaling appear to make it particularly well suited to signal integration, including its responsiveness to cell-cell contact and the mediation of its transcriptional output by transcriptional co-activator proteins that can interact with transcription factors of other pathways.

References

Jul 22, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R W PadgettS Krishna
Jul 23, 2004·Journal of Biochemistry·Hiroshi Kanda, Masayuki Miura
Dec 13, 2005·Nature·Craig A Micchelli, Norbert Perrimon
Dec 13, 2005·Nature·Benjamin Ohlstein, Allan Spradling
May 12, 2006·Development·Hitoshi Matakatsu, Seth S Blair
Sep 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·L A Baena-Lopez, A García-Bellido
Sep 19, 2006·Nature Genetics·Eunjoo ChoKenneth D Irvine
Sep 26, 2006·Current Biology : CB·Maria WilleckeGeorg Halder
Oct 19, 2006·Current Biology : CB·F Christian Bennett, Kieran F Harvey
Feb 8, 2008·Development·Hyangyee Oh, Kenneth D Irvine
Mar 25, 2008·Cytokine & Growth Factor Reviews·Xu Shi-WenDavid Abraham
Jun 24, 2008·Nature Cell Biology·Xaralabos VarelasJeffrey L Wrana
Jun 27, 2008·Genes & Development·Bin ZhaoKun-Liang Guan
Jul 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Luis Alberto Baena-LopezAntonio Baonza
Jul 18, 2008·Cancer Research·Ying-Ka Ingar LauQin Yu
Jul 19, 2008·Science·Hiroyuki O IshikawaKenneth D Irvine
Aug 13, 2008·Developmental Cell·Dragana RoguljaKenneth D Irvine
Sep 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Maria WilleckeGeorg Halder
Nov 19, 2008·Genes & Development·Xinwei CaoFred H Gage
Nov 26, 2008·Oncogene·P O HumbertH E Richardson
Dec 25, 2008·Cell Cycle·Efrem BertiniGiovanni Blandino
Jan 9, 2009·Cell Stem Cell·Alla AmcheslavskyY Tony Ip

❮ Previous
Next ❯

Citations

May 7, 2014·The Journal of Cell Biology·Jianhua Huang, Daniel Kalderon
Sep 12, 2013·Science Signaling·Gongping Sun, Kenneth D Irvine
May 16, 2013·Science Signaling·Emad Heidary Arash, Liliana Attisano
Apr 24, 2013·Trends in Cell Biology·Ilenia Bernascone, Fernando Martin-Belmonte
Dec 4, 2014·Journal of Drug Targeting·Delin KongChun-Bo Teng
Feb 4, 2015·International Journal of Cancer. Journal International Du Cancer·Benjamin YeungXiaolong Yang
Jan 14, 2016·Nature Communications·Joseph H A VissersKieran F Harvey
Sep 22, 2015·Frontiers in Oncology·Michael D DeelCorinne M Linardic
May 23, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hiroki GotohLaura C Lavine
Jan 27, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alexis Matamoro-VidalDavid Houle
Aug 13, 2015·Developmental Cell·Iswar K Hariharan
Mar 15, 2013·Developmental Cell·B V V G Reddy, Kenneth D Irvine
Dec 6, 2014·Acta Biochimica Et Biophysica Sinica·Meng-Xin Yin, Lei Zhang
Dec 2, 2014·Nature Cell Biology·Biao MaShian Wu
Aug 25, 2016·Scientific Reports·Sepideh VahidAmina Zoubeidi
Dec 5, 2017·Journal of the National Cancer Institute·David Sánchez-MartínGiovanna Tosato
Sep 6, 2018·Annual Review of Genetics·Jyoti R Misra, Kenneth D Irvine
Mar 8, 2013·Nature Reviews. Cancer·Kieran F HarveyDavid M Thomas
Feb 26, 2015·The EMBO Journal·Georgina C FletcherBarry J Thompson
Nov 27, 2014·The EMBO Journal·Emad Heidary ArashLiliana Attisano
Feb 12, 2017·EMBO Reports·Emad Heidary ArashLiliana Attisano
Jan 18, 2020·Journal of Cellular Physiology·Abolfazl BarzegariGraciela Pavon-Djavid
Dec 13, 2019·Stem Cells·Larry Sai Weng LooRohit N Kulkarni
Dec 11, 2019·DNA and Cell Biology·Cong ZhangXiaotao Wu
Jan 10, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Jia GouHans G Othmer
Jan 18, 2018·Oncotarget·Yaopan MaoKenneth D Irvine
Aug 7, 2014·Clinical and Translational Medicine·Daniel A Barron, Jacob D Kagey
Dec 1, 2014·Clinical and Translational Medicine·Dominic P Del Re
Aug 5, 2020·Basic Research in Cardiology·Naisam AbbasThomas Thum
May 15, 2020·Nature Communications·Noreen EderSila K Ultanir
May 14, 2017·G3 : Genes - Genomes - Genetics·Jordi Leno-ColoradoMiguel Pérez-Enciso
May 8, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Changyong LiBibo Ke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.