Integration of molecular characterization of microorganisms in a global antimicrobial resistance surveillance program

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Michael A. PfallerH S Sader

Abstract

The SENTRY Antimicrobial Surveillance Program has incorporated molecular strain typing and resistance genotyping as a means of providing additional information that may be useful for understanding pathogenic microorganisms worldwide. Resistance phenotypes of interest include multidrug-resistant pathogens, extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci, and fluoroquinolone-resistant (FQR) strains of gram-negative bacilli and Streptococcus pneumoniae. Clusters of > or =2 isolates within a given resistance profile that are linked temporally and by hospital location are flagged for DNA fingerprinting. Further characterization of organisms with respect to resistance genotype is accomplished with use of polymerase chain reaction and DNA sequencing. This process has been highly successful in identifying clonal spread within clusters of multiresistant pathogens. Between 50% and 90% of MRSA clusters identified by phenotypic screening contained evidence of clonal spread. Among the Enterobacteriaceae, ESBL-producing strains of Escherichia coli and Klebsiella pneumoniae are the most common pathogens causing clusters of infection, and...Continue Reading

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Citations

Jan 5, 2002·Diagnostic Microbiology and Infectious Disease·M A PfallerUNKNOWN MYSTIC Program Study Group
Jan 9, 2004·Diagnostic Microbiology and Infectious Disease·Suzane SilbertMichael A Pfaller
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Mar 22, 2019·Open Forum Infectious Diseases·Helio S SaderRonald N Jones

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