Integration of P2Y receptor-activated signal transduction pathways in G protein-dependent signalling networks.

Purinergic Signalling
Kristof Van Kolen, Herman Slegers

Abstract

The role of nucleotides in intracellular energy provision and nucleic acid synthesis has been known for a long time. In the past decade, evidence has been presented that, in addition to these functions, nucleotides are also autocrine and paracrine messenger molecules that initiate and regulate a large number of biological processes. The actions of extracellular nucleotides are mediated by ionotropic P2X and metabotropic P2Y receptors, while hydrolysis by ecto-enzymes modulates the initial signal. An increasing number of studies have been performed to obtain information on the signal transduction pathways activated by nucleotide receptors. The development of specific and stable purinergic receptor agonists and antagonists with therapeutical potential largely contributed to the identification of receptors responsible for nucleotide-activated pathways. This article reviews the signal transduction pathways activated by P2Y receptors, the involved second messenger systems, GTPases and protein kinases, as well as recent findings concerning P2Y receptor signalling in C6 glioma cells. Besides vertical signal transduction, lateral cross-talks with pathways activated by other G protein-coupled receptors and growth factor receptors are di...Continue Reading

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Citations

Mar 28, 2008·Purinergic Signalling·I Novak
Nov 19, 2009·Purinergic Signalling·Elena Bulanova, Silvia Bulfone-Paus
Sep 2, 2010·Purinergic Signalling·Lin-Chien HuangGary D Housley
Dec 29, 2012·Purinergic Signalling·Tania MartiáñezAlejandro Gella
Jul 2, 2008·Nature Reviews. Drug Discovery·Geoffrey Burnstock
Feb 19, 2009·Acta Physiologica·G Burnstock, A Verkhratsky
Mar 30, 2010·Acta Physiologica·G BurnstockA Verkhratsky
Sep 15, 2009·PloS One·Sang Ok Song, Jeffrey Varner
May 11, 2010·Archives of Biochemistry and Biophysics·Paola Scodelaro BilbaoRicardo Boland
Nov 11, 2009·Archives of Biochemistry and Biophysics·Paola Scodelaro BilbaoGraciela Santillán
Jan 10, 2008·Journal of Neuroscience Research·Yasuhiro IrinoKeiko Ohsawa
Jan 14, 2010·Biochemical Pharmacology·Ramachandran BalasubramanianKenneth A Jacobson
Jun 10, 2014·Basic & Clinical Pharmacology & Toxicology·Ana Sofia SoaresPaula Fresco
Nov 18, 2014·Biochemical Society Transactions·Xin HuiPeter Lipp
Dec 3, 2011·Biochemical and Biophysical Research Communications·Satohiko KunugiKoichi Kawahara
May 1, 2016·Seminars in Immunopathology·Shih Han Tsai, Kiyoshi Takeda
Oct 13, 2017·Purinergic Signalling·Gabriela Pimenta-Dos-ReisJulieta Schachter
Nov 30, 2018·The Journal of Biological Chemistry·Gerard Cantero-RecasensVivek Malhotra
Jan 12, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Angela K MossRichard A Hodin

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Methods Mentioned

BETA
GTPases
nucleotide exchange
transfection
co-immunoprecipitation

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