Integration of Peripheral and Glandular Regulation of Triiodothyronine Production by Thyrotropin in Untreated and Thyroxine-Treated Subjects

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
R HoermannJ W Dietrich

Abstract

The objective of the study was to evaluate the roles of central and peripheral T3 regulation. In a prospective study involving 1,796 patients, the equilibria between FT3 and TSH were compared in untreated and L-T4-treated patients with varying functional states, residual thyroid secretory capacities and magnitudes of TSH stimulation. T3 concentrations were stable over wide variations in TSH levels (from 0.2 to 7 mU/l) and endogenous T4 production in untreated patients, but unbalanced in L-T4-treated athyreotic patients where T3 correlated with exogenous T4 supply. T3 stability was related to TSH-stimulated deiodinase activity by clinical observation, as predicted by theoretical modelling. Deiodinase activity in treated patients was reduced due to both diminished responsiveness to TSH and lack of thyroidal capacity. Deiodinase activity was increased in high thyroid volume, compared to lower volumes in euthyroid patients (<5 ml, p<0.001). While deiodinase differed between euthyroid and subclinically hypothyroid patients in high volume, 26.7 nmol/s (23.6, 29.2), n=214 vs. 28.9 nmol/s (26.7, 31.5), n=20, p=0.02, it was equivalent between the 2 functional groups in low volume, 23.3 nmol/s (21.3, 26.1), n=117 vs. 24.6 nmol/s (22.2, 2...Continue Reading

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Jun 1, 2019·Johannes W. Dietrich
Sep 1, 2020·Johannes W. Dietrich
Jul 4, 2018·Johannes W. Dietrich
Jul 3, 2018·Johannes W. Dietrich
Jul 3, 2018·Johannes W. Dietrich
Jul 3, 2018·Johannes W. Dietrich
Jul 4, 2018·Johannes W. Dietrich
Jul 3, 2018·Johannes W. Dietrich
Apr 1, 2020·Johannes W. Dietrich

Citations

Nov 23, 2015·The Lancet. Diabetes & Endocrinology·Johannes W DietrichRudolf Hoermann
Sep 24, 2015·European Journal of Endocrinology·Eleonore Fröhlich, Richard Wahl
Nov 7, 2015·Current Opinion in Oncology·Jacqueline Jonklaas
Dec 5, 2015·Frontiers in Endocrinology·Rudolf HoermannJohannes W Dietrich
Jul 5, 2016·Frontiers in Endocrinology·Johannes W DietrichRudolf Hoermann
May 4, 2016·Expert Review of Clinical Pharmacology·Jacqueline Jonklaas
Jan 30, 2018·Frontiers in Endocrinology·Rudolf HoermannJohannes W Dietrich
Jul 20, 2018·European Journal of Clinical Investigation·Rudolf HoermannJohannes W Dietrich
Aug 15, 2019·Thyroid : Official Journal of the American Thyroid Association·Mitsuru ItoAkira Miyauchi
Dec 10, 2019·European Journal of Clinical Investigation·Rudolf HoermannJohannes W Dietrich
Apr 6, 2018·Frontiers in Endocrinology·Julian BerberichMatthias A Müller
Apr 1, 2016·Thyroid : Official Journal of the American Thyroid Association·Jacqueline Jonklaas, Kenneth D Burman
Aug 11, 2017·Therapeutic Advances in Endocrinology and Metabolism·Rudolf HoermannRolf Larisch
Nov 23, 2016·Frontiers in Endocrinology·Rudolf HoermannJohannes W Dietrich
Nov 21, 2017·PloS One·Rudolf HoermannJohannes Wolfgang Christian Dietrich
Jun 21, 2018·Frontiers in Endocrinology·Johannes W DietrichRudolf Hoermann
Apr 11, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Xiaomin NieYuqian Bao
Sep 21, 2021·Endocrine Reviews·Jacqueline Jonklaas

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