Integration of phytochemicals and phytotherapy into cancer precision medicine

Oncotarget
Thomas EfferthSalah Daak

Abstract

Concepts of individualized therapy in the 1970s and 1980s attempted to develop predictive in vitro tests for individual drug responsiveness without reaching clinical routine. Precision medicine attempts to device novel individual cancer therapy strategies. Using bioinformatics, relevant knowledge is extracted from huge data amounts. However, tumor heterogeneity challenges chemotherapy due to genetically and phenotypically different cell subpopulations, which may lead to refractory tumors. Natural products always served as vital resources for cancer therapy (e.g., Vinca alkaloids, camptothecin, paclitaxel, etc.) and are also sources for novel drugs. Targeted drugs developed to specifically address tumor-related proteins represent the basis of precision medicine. Natural products from plants represent excellent resource for targeted therapies. Phytochemicals and herbal mixtures act multi-specifically, i.e. they attack multiple targets at the same time. Network pharmacology facilitates the identification of the complexity of pharmacogenomic networks and new signaling networks that are distorted in tumors. In the present review, we give a conceptual overview, how the problem of drug resistance may be approached by integrating phyto...Continue Reading

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Citations

Mar 6, 2018·Advanced Materials·Yilong WangDonglu Shi
Jun 18, 2019·Current Medicinal Chemistry·Carmelo PugliaElisabetta Esposito
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Apr 24, 2021·Critical Reviews in Food Science and Nutrition·Francine C CadonáFloriano Paes Silva-Jr

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Methods Mentioned

BETA
histone acetylation
fluorescence-activated cell sorting
single-cell sequencing
nuclear translocation
Chip
ubiquitination
protein knockouts

Software Mentioned

Ingenuity Pathway Analysis software ( IPA
Ingenuity
Chipster

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